Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson’s Disease via GABAergic Pathway

BACKGROUND/AIMS: Hypersensitive pain response is often observed in patients with Parkinson’s disease (PD); however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Since the midbrain periaqueductal gray (PA...

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Detalles Bibliográficos
Autores principales: Zhuang, Xianbo, Chen, Yanxiu, Zhuang, Xianpeng, Chen, Tuanzhi, Xing, Tao, Wang, Weifei, Yang, Xiafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959028/
https://www.ncbi.nlm.nih.gov/pubmed/27504103
http://dx.doi.org/10.3389/fneur.2016.00104

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