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Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study
BACKGROUND: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
W.B. Saunders
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959416/ https://www.ncbi.nlm.nih.gov/pubmed/27423344 http://dx.doi.org/10.1016/j.comppsych.2016.05.004 |
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author | Siebald, Caroline Khandaker, Golam M. Zammit, Stanley Lewis, Glyn Jones, Peter B. |
author_facet | Siebald, Caroline Khandaker, Golam M. Zammit, Stanley Lewis, Glyn Jones, Peter B. |
author_sort | Siebald, Caroline |
collection | PubMed |
description | BACKGROUND: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. METHOD: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. RESULTS: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. CONCLUSIONS: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors. |
format | Online Article Text |
id | pubmed-4959416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | W.B. Saunders |
record_format | MEDLINE/PubMed |
spelling | pubmed-49594162016-08-01 Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study Siebald, Caroline Khandaker, Golam M. Zammit, Stanley Lewis, Glyn Jones, Peter B. Compr Psychiatry Article BACKGROUND: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. METHOD: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. RESULTS: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. CONCLUSIONS: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors. W.B. Saunders 2016-08 /pmc/articles/PMC4959416/ /pubmed/27423344 http://dx.doi.org/10.1016/j.comppsych.2016.05.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Siebald, Caroline Khandaker, Golam M. Zammit, Stanley Lewis, Glyn Jones, Peter B. Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title_full | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title_fullStr | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title_full_unstemmed | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title_short | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
title_sort | association between childhood psychiatric disorders and psychotic experiences in adolescence: a population-based longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959416/ https://www.ncbi.nlm.nih.gov/pubmed/27423344 http://dx.doi.org/10.1016/j.comppsych.2016.05.004 |
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