Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response

Spliceosomal SNRNP200 is a Ski2-like RNA helicase that is associated with retinitis pigmentosa 33 (RP33). Here we found that SNRNP200 promotes viral RNA sensing and IRF3 activation through the ability of its amino-terminal Sec63 domain (Sec63-1) to bind RNA and to interact with TBK1. We show that SN...

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Detalles Bibliográficos
Autores principales: Tremblay, Nicolas, Baril, Martin, Chatel-Chaix, Laurent, Es-Saad, Salwa, Park, Alex Young, Koenekoop, Robert K., Lamarre, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959778/
https://www.ncbi.nlm.nih.gov/pubmed/27454487
http://dx.doi.org/10.1371/journal.ppat.1005772

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