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Integrative neuromechanics of crawling in D. melanogaster larvae
Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959844/ http://dx.doi.org/10.7554/eLife.11031 |
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author | Pehlevan, Cengiz Paoletti, Paolo Mahadevan, L |
author_facet | Pehlevan, Cengiz Paoletti, Paolo Mahadevan, L |
author_sort | Pehlevan, Cengiz |
collection | PubMed |
description | Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior. DOI: http://dx.doi.org/10.7554/eLife.11031.001 |
format | Online Article Text |
id | pubmed-4959844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49598442016-07-28 Integrative neuromechanics of crawling in D. melanogaster larvae Pehlevan, Cengiz Paoletti, Paolo Mahadevan, L eLife Computational and Systems Biology Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior. DOI: http://dx.doi.org/10.7554/eLife.11031.001 eLife Sciences Publications, Ltd 2016-07-25 /pmc/articles/PMC4959844/ http://dx.doi.org/10.7554/eLife.11031 Text en © 2016, Pehlevan et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Pehlevan, Cengiz Paoletti, Paolo Mahadevan, L Integrative neuromechanics of crawling in D. melanogaster larvae |
title | Integrative neuromechanics of crawling in D. melanogaster larvae |
title_full | Integrative neuromechanics of crawling in D. melanogaster larvae |
title_fullStr | Integrative neuromechanics of crawling in D. melanogaster larvae |
title_full_unstemmed | Integrative neuromechanics of crawling in D. melanogaster larvae |
title_short | Integrative neuromechanics of crawling in D. melanogaster larvae |
title_sort | integrative neuromechanics of crawling in d. melanogaster larvae |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959844/ http://dx.doi.org/10.7554/eLife.11031 |
work_keys_str_mv | AT pehlevancengiz integrativeneuromechanicsofcrawlingindmelanogasterlarvae AT paolettipaolo integrativeneuromechanicsofcrawlingindmelanogasterlarvae AT mahadevanl integrativeneuromechanicsofcrawlingindmelanogasterlarvae |