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Integrative neuromechanics of crawling in D. melanogaster larvae

Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our...

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Detalles Bibliográficos
Autores principales: Pehlevan, Cengiz, Paoletti, Paolo, Mahadevan, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959844/
http://dx.doi.org/10.7554/eLife.11031
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author Pehlevan, Cengiz
Paoletti, Paolo
Mahadevan, L
author_facet Pehlevan, Cengiz
Paoletti, Paolo
Mahadevan, L
author_sort Pehlevan, Cengiz
collection PubMed
description Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior. DOI: http://dx.doi.org/10.7554/eLife.11031.001
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spelling pubmed-49598442016-07-28 Integrative neuromechanics of crawling in D. melanogaster larvae Pehlevan, Cengiz Paoletti, Paolo Mahadevan, L eLife Computational and Systems Biology Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior. DOI: http://dx.doi.org/10.7554/eLife.11031.001 eLife Sciences Publications, Ltd 2016-07-25 /pmc/articles/PMC4959844/ http://dx.doi.org/10.7554/eLife.11031 Text en © 2016, Pehlevan et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Pehlevan, Cengiz
Paoletti, Paolo
Mahadevan, L
Integrative neuromechanics of crawling in D. melanogaster larvae
title Integrative neuromechanics of crawling in D. melanogaster larvae
title_full Integrative neuromechanics of crawling in D. melanogaster larvae
title_fullStr Integrative neuromechanics of crawling in D. melanogaster larvae
title_full_unstemmed Integrative neuromechanics of crawling in D. melanogaster larvae
title_short Integrative neuromechanics of crawling in D. melanogaster larvae
title_sort integrative neuromechanics of crawling in d. melanogaster larvae
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959844/
http://dx.doi.org/10.7554/eLife.11031
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