Cargando…

Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

Increasing evidence highlights the important roles of microRNAs in mediating p53’s tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Bo, Wang, Kebing, Liao, Jun-Ming, Zhou, Xiang, Liao, Peng, Zeng, Shelya X, He, Meifang, Chen, Lianzhou, He, Yulong, Li, Wen, Lu, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959878/ https://www.ncbi.nlm.nih.gov/pubmed/27383270 http://dx.doi.org/10.7554/eLife.15978

Ejemplares similares

MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway
por: Huang, Peng, et al.
Publicado: (2021)

Phosphodiesterases and cAMP Pathway in Pituitary Diseases
por: Bizzi, Mariana Ferreira, et al.
Publicado: (2019)

Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
por: Zhou, Xiang, et al.
Publicado: (2016)

Revisiting the roles of cAMP signalling in the progression of prostate cancer
por: Parsons, Emma C., et al.
Publicado: (2023)

SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer
por: Fang, Ziling, et al.
Publicado: (2018)

Global Effect of Inauhzin on Human p53-Responsive Transcriptome
por: Liao, Jun-Ming, et al.
Publicado: (2012)

It takes a team: a gain-of-function story of p53-R249S
por: Wang, Huai, et al.
Publicado: (2019)

An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing
por: Johnson, Keven R, et al.
Publicado: (2010)

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
por: Park, Sung-Jun, et al.
Publicado: (2012)

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection
por: Evripioti, Antonia Alexandra, et al.
Publicado: (2019)

Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue
por: Ponsaerts, Laura, et al.
Publicado: (2021)

A cAMP phosphodiesterase is essential for sclerotia formation and virulence in Sclerotinia sclerotiorum
por: Xu, Yan, et al.
Publicado: (2023)

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis
por: Venkatakrishnan, Varun, et al.
Publicado: (2023)

Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis
por: Jiang, Leiwei, et al.
Publicado: (2020)

p53 induces ARTS to promote mitochondrial apoptosis
por: Hao, Qian, et al.
Publicado: (2021)

Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway
por: Sato, Yukuto, et al.
Publicado: (2009)

Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response()
por: Matange, Nishad, et al.
Publicado: (2013)

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4
por: Perera, Ruwan K., et al.
Publicado: (2017)

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion
por: Flueck, Christian, et al.
Publicado: (2019)

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii
por: Vo, Kim Chi, et al.
Publicado: (2022)

Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs
por: Leuchs, Simon, et al.
Publicado: (2012)

RNA-binding Motif Protein 10 Induces Apoptosis and Suppresses Proliferation by Activating p53
por: Jung, Ji Hoon, et al.
Publicado: (2019)

RBM10, a New Regulator of p53
por: Jung, Ji Hoon, et al.
Publicado: (2020)

P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis
por: Patritti Cram, Jennifer, et al.
Publicado: (2022)

Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma
por: Okada, Reona, et al.
Publicado: (2020)

The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations
por: Oliveira, Rodrigo F., et al.
Publicado: (2010)

Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins
por: Tibbo, Amy J., et al.
Publicado: (2022)

Functional Analysis of Two Affinity cAMP Phosphodiesterases in the Nematode-Trapping Fungus Arthrobotrys oligospora
por: Ma, Ni, et al.
Publicado: (2022)

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance
por: Walia, Mannu K, et al.
Publicado: (2016)

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
por: Henderson, D J P, et al.
Publicado: (2014)

Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion
por: Staun-Ram, Elsebeth, et al.
Publicado: (2009)

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53
por: Walia, Mannu K., et al.
Publicado: (2018)

cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
por: Skah, Seham, et al.
Publicado: (2018)

Inhibition of cAMP phosphodiesterase by milrinone improves cardiac recovery after deep hypothermic circulatory arrest
por: Troitzsch, D, et al.
Publicado: (2001)

Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
por: Cho, Eun Sook, et al.
Publicado: (2005)

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II
por: Mokni, Walid, et al.
Publicado: (2010)

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM
por: Zhang, Fan, et al.
Publicado: (2015)

Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase
por: Cadby, Ian T, et al.
Publicado: (2019)

Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells
por: Lounas, Amel, et al.
Publicado: (2019)

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
por: Calamera, Gaia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1biiejketj96t4vv9getj4gnqq