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Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine

We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. Afte...

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Autores principales: O'Laughlin, John P., Mehta, Parag H., Wong, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960328/
https://www.ncbi.nlm.nih.gov/pubmed/27478650
http://dx.doi.org/10.1155/2016/4626279
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author O'Laughlin, John P.
Mehta, Parag H.
Wong, Brian C.
author_facet O'Laughlin, John P.
Mehta, Parag H.
Wong, Brian C.
author_sort O'Laughlin, John P.
collection PubMed
description We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient's QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure.
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spelling pubmed-49603282016-07-31 Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine O'Laughlin, John P. Mehta, Parag H. Wong, Brian C. Case Rep Cardiol Case Report We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient's QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. Hindawi Publishing Corporation 2016 2016-07-12 /pmc/articles/PMC4960328/ /pubmed/27478650 http://dx.doi.org/10.1155/2016/4626279 Text en Copyright © 2016 John P. O'Laughlin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
O'Laughlin, John P.
Mehta, Parag H.
Wong, Brian C.
Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title_full Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title_fullStr Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title_full_unstemmed Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title_short Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
title_sort life threatening severe qtc prolongation in patient with systemic lupus erythematosus due to hydroxychloroquine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960328/
https://www.ncbi.nlm.nih.gov/pubmed/27478650
http://dx.doi.org/10.1155/2016/4626279
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