Brain tumor imaging of rat fresh tissue using terahertz spectroscopy

Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model. The complex refractive index spectrum obtained by a reflection terahertz time-domain spectroscopy system can discriminate between normal and tumor tissues. Both the refractive i...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Sayuri, Fukushi, Yasuko, Kubota, Oichi, Itsuji, Takeaki, Ouchi, Toshihiko, Yamamoto, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960480/
https://www.ncbi.nlm.nih.gov/pubmed/27456312
http://dx.doi.org/10.1038/srep30124
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author Yamaguchi, Sayuri
Fukushi, Yasuko
Kubota, Oichi
Itsuji, Takeaki
Ouchi, Toshihiko
Yamamoto, Seiji
author_facet Yamaguchi, Sayuri
Fukushi, Yasuko
Kubota, Oichi
Itsuji, Takeaki
Ouchi, Toshihiko
Yamamoto, Seiji
author_sort Yamaguchi, Sayuri
collection PubMed
description Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model. The complex refractive index spectrum obtained by a reflection terahertz time-domain spectroscopy system can discriminate between normal and tumor tissues. Both the refractive index and absorption coefficient of tumor tissues are higher than those of normal tissues and can be attributed to the higher cell density and water content of the tumor region. The results of this study indicate that terahertz technology is useful for detecting brain tumor tissue.
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spelling pubmed-49604802016-08-04 Brain tumor imaging of rat fresh tissue using terahertz spectroscopy Yamaguchi, Sayuri Fukushi, Yasuko Kubota, Oichi Itsuji, Takeaki Ouchi, Toshihiko Yamamoto, Seiji Sci Rep Article Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model. The complex refractive index spectrum obtained by a reflection terahertz time-domain spectroscopy system can discriminate between normal and tumor tissues. Both the refractive index and absorption coefficient of tumor tissues are higher than those of normal tissues and can be attributed to the higher cell density and water content of the tumor region. The results of this study indicate that terahertz technology is useful for detecting brain tumor tissue. Nature Publishing Group 2016-07-26 /pmc/articles/PMC4960480/ /pubmed/27456312 http://dx.doi.org/10.1038/srep30124 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yamaguchi, Sayuri
Fukushi, Yasuko
Kubota, Oichi
Itsuji, Takeaki
Ouchi, Toshihiko
Yamamoto, Seiji
Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title_full Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title_fullStr Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title_full_unstemmed Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title_short Brain tumor imaging of rat fresh tissue using terahertz spectroscopy
title_sort brain tumor imaging of rat fresh tissue using terahertz spectroscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960480/
https://www.ncbi.nlm.nih.gov/pubmed/27456312
http://dx.doi.org/10.1038/srep30124
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