Cargando…

Identification and characterization of the role of c-terminal Src kinase in dengue virus replication

We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication. Knock-down of Csk expression by siRNAs or inhibition of Csk by an inhibitor reduced dengue virus RNA levels but did not a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Rinki, Agrawal, Tanvi, Khan, Naseem Ahmed, Nakayama, Yuji, Medigeshi, Guruprasad R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960526/ https://www.ncbi.nlm.nih.gov/pubmed/27457684 http://dx.doi.org/10.1038/srep30490

Ejemplares similares

N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle
por: Medigeshi, Guruprasad R., et al.
Publicado: (2016)

Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection
por: Kumar, Rinki, et al.
Publicado: (2018)

Zinc Chelation Specifically Inhibits Early Stages of Dengue Virus Replication by Activation of NF-κB and Induction of Antiviral Response in Epithelial Cells
por: Kar, Meenakshi, et al.
Publicado: (2019)

Dengue virus replication enhances labile zinc pools by modulation of ZIP8
por: Panwar, Aleksha, et al.
Publicado: (2021)

Dengue Virus Entry and Replication Does Not Lead to Productive Infection in Platelets
por: Kar, Meenakshi, et al.
Publicado: (2017)

Japanese Encephalitis Virus Disrupts Cell-Cell Junctions and Affects the Epithelial Permeability Barrier Functions
por: Agrawal, Tanvi, et al.
Publicado: (2013)

CORRIGENDUM: Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle
por: Agrawal, Tanvi, et al.
Publicado: (2014)

Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle
por: Agrawal, Tanvi, et al.
Publicado: (2013)

Humoral cross-reactivity towards SARS-CoV-2 in young children with acute respiratory infection with low-pathogenicity coronaviruses
por: Dhochak, Nitin, et al.
Publicado: (2022)

Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells
por: Khan, Naseem Ahmed, et al.
Publicado: (2020)

Neutralizing antibodies from prior exposure to dengue virus negatively correlate with viremia on re-infection
por: Anantharaj, Anbalagan, et al.
Publicado: (2023)

Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport
por: Panwar, Aleksha, et al.
Publicado: (2023)

Bispidine-Amino Acid Conjugates Act as a Novel Scaffold for the Design of Antivirals That Block Japanese Encephalitis Virus Replication
por: Haridas, V., et al.
Publicado: (2013)

C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src
por: Samarasekera, G. D. N. Gayathri, et al.
Publicado: (2018)

C‐terminal Src kinase‐mediated EPIYA phosphorylation of Pragmin creates a feed‐forward C‐terminal Src kinase activation loop that promotes cell motility
por: Senda, Yoshie, et al.
Publicado: (2016)

Inhibition of protein kinase C promotes dengue virus replication
por: Noppakunmongkolchai, Warobon, et al.
Publicado: (2016)

Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity
por: Singla, Mohit, et al.
Publicado: (2016)

Correction: Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity
por: Singla, Mohit, et al.
Publicado: (2016)

A Non-Replicative Role of the 3′ Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation
por: Cerikan, Berati, et al.
Publicado: (2020)

Structure and Characterization of a Covalent Inhibitor of Src Kinase
por: Gurbani, Deepak, et al.
Publicado: (2020)

The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2012)

Protective role for lipid modifications of Src-family kinases against chromosome missegregation
por: Honda, Takuya, et al.
Publicado: (2016)

The tyrosine kinase v‐Src modifies cytotoxicities of anticancer drugs targeting cell division
por: Yuki, Ryuzaburo, et al.
Publicado: (2021)

Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India
por: Chandele, Anmol, et al.
Publicado: (2016)

v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling
por: Honda, Takuya, et al.
Publicado: (2018)

Autonomous Maturation of α/β T Lineage Cells in the Absence of Cooh-Terminal Src Kinase (Csk)
por: Schmedt, Christian, et al.
Publicado: (2001)

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
por: Manocha, Gunjan D., et al.
Publicado: (2015)

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
por: Vang, Torkel, et al.
Publicado: (2001)

Timeless Links Replication Termination to Mitotic Kinase Activation
por: Dheekollu, Jayaraju, et al.
Publicado: (2011)

Position Paper on Road Map for RNA Virus Research in India
por: Medigeshi, Guruprasad R., et al.
Publicado: (2018)

Recent advances in the identification of the host factors involved in dengue virus replication
por: Wang, Yi, et al.
Publicado: (2017)

Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling
por: Liu, Dongsheng, et al.
Publicado: (2016)

Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase
por: Liu, Dongsheng, et al.
Publicado: (2016)

Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments
por: Guo, Xiaohua, et al.
Publicado: (2020)

Platelet activation determines the severity of thrombocytopenia in dengue infection
por: Ojha, Amrita, et al.
Publicado: (2017)

CD8 T cells protect adult naive mice from JEV-induced morbidity via lytic function
por: Jain, Nidhi, et al.
Publicado: (2017)

Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses
por: Anantharaj, Anbalagan, et al.
Publicado: (2022)

Targeting the Src N-terminal regulatory element in cancer
por: Mezquita, Betlem, et al.
Publicado: (2023)

Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity
por: Mezquita, Belén, et al.
Publicado: (2014)

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine
por: Advani, Gahana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_itl02goo1ku3rg4m4cvfhj57bn