Cargando…
Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vacci...
Autores principales: | Hjerrild, Kathryn A., Jin, Jing, Wright, Katherine E., Brown, Rebecca E., Marshall, Jennifer M., Labbé, Geneviève M., Silk, Sarah E., Cherry, Catherine J., Clemmensen, Stine B., Jørgensen, Thomas, Illingworth, Joseph J., Alanine, Daniel G. W., Milne, Kathryn H., Ashfield, Rebecca, de Jongh, Willem A., Douglas, Alexander D., Higgins, Matthew K., Draper, Simon J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960544/ https://www.ncbi.nlm.nih.gov/pubmed/27457156 http://dx.doi.org/10.1038/srep30357 |
Ejemplares similares
-
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies
por: Wright, Katherine E., et al.
Publicado: (2014) -
Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’
por: Jin, Jing, et al.
Publicado: (2017) -
Production of Ebola virus-like particles in Drosophila melanogaster Schneider 2 cells
por: Park, Eun-Mee, et al.
Publicado: (2018) -
Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells
por: Jin, Jing, et al.
Publicado: (2018) -
A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys
por: Douglas, Alexander D., et al.
Publicado: (2015)