DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs

The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing correspondi...

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Detalles Bibliográficos
Autores principales: Cheng, Liang, Jiang, Yue, Wang, Zhenzhen, Shi, Hongbo, Sun, Jie, Yang, Haixiu, Zhang, Shuo, Hu, Yang, Zhou, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960572/
https://www.ncbi.nlm.nih.gov/pubmed/27457921
http://dx.doi.org/10.1038/srep30024
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author Cheng, Liang
Jiang, Yue
Wang, Zhenzhen
Shi, Hongbo
Sun, Jie
Yang, Haixiu
Zhang, Shuo
Hu, Yang
Zhou, Meng
author_facet Cheng, Liang
Jiang, Yue
Wang, Zhenzhen
Shi, Hongbo
Sun, Jie
Yang, Haixiu
Zhang, Shuo
Hu, Yang
Zhou, Meng
author_sort Cheng, Liang
collection PubMed
description The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim.
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spelling pubmed-49605722016-08-05 DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs Cheng, Liang Jiang, Yue Wang, Zhenzhen Shi, Hongbo Sun, Jie Yang, Haixiu Zhang, Shuo Hu, Yang Zhou, Meng Sci Rep Article The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim. Nature Publishing Group 2016-07-26 /pmc/articles/PMC4960572/ /pubmed/27457921 http://dx.doi.org/10.1038/srep30024 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cheng, Liang
Jiang, Yue
Wang, Zhenzhen
Shi, Hongbo
Sun, Jie
Yang, Haixiu
Zhang, Shuo
Hu, Yang
Zhou, Meng
DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title_full DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title_fullStr DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title_full_unstemmed DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title_short DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
title_sort dissim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960572/
https://www.ncbi.nlm.nih.gov/pubmed/27457921
http://dx.doi.org/10.1038/srep30024
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