Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion

There is often interest in dissecting the relative contributions of the N-glycans, O-glycans and glycosphingolipids (GSLs) in regulating complex biological traits like cell signaling, adhesion, development and metastasis. To address this, we developed a CRISPR-Cas9 toolkit to selectively truncate ea...

Descripción completa

Detalles Bibliográficos
Autores principales: Stolfa, Gino, Mondal, Nandini, Zhu, Yuqi, Yu, Xinheng, Buffone, Alexander, Neelamegham, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960646/
https://www.ncbi.nlm.nih.gov/pubmed/27458028
http://dx.doi.org/10.1038/srep30392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960646/
https://www.ncbi.nlm.nih.gov/pubmed/27458028
http://dx.doi.org/10.1038/srep30392

Ejemplares similares