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miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

BACKGROUND: Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson’s disease (PD). PINK1 is a mitochondrial serine/threonine kinase that plays a critical role in mitophagy, a selective autophagic clearance of damaged mitochondria. Accumulating evid...

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Detalles Bibliográficos
Autores principales:	Kim, Jaekwang, Fiesel, Fabienne C., Belmonte, Krystal C., Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter T., Springer, Wolfdieter, Kim, Jungsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960690/ https://www.ncbi.nlm.nih.gov/pubmed/27456084 http://dx.doi.org/10.1186/s13024-016-0121-4

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