Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

BACKGROUND: Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, trigge...

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Detalles Bibliográficos
Autores principales: Nelson, David M., Jaber-Hijazi, Farah, Cole, John J., Robertson, Neil A., Pawlikowski, Jeffrey S., Norris, Kevin T., Criscione, Steven W., Pchelintsev, Nikolay A., Piscitello, Desiree, Stong, Nicholas, Rai, Taranjit Singh, McBryan, Tony, Otte, Gabriel L., Nixon, Colin, Clark, William, Riethman, Harold, Wu, Hong, Schotta, Gunnar, Garcia, Benjamin A., Neretti, Nicola, Baird, Duncan M., Berger, Shelley L., Adams, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960804/
https://www.ncbi.nlm.nih.gov/pubmed/27457071
http://dx.doi.org/10.1186/s13059-016-1017-x

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