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Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia
BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960818/ https://www.ncbi.nlm.nih.gov/pubmed/27457769 http://dx.doi.org/10.1186/s12876-016-0495-3 |
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author | Friesen, Craig A. Rosen, John M. Schurman, Jennifer V. |
author_facet | Friesen, Craig A. Rosen, John M. Schurman, Jennifer V. |
author_sort | Friesen, Craig A. |
collection | PubMed |
description | BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms. METHODS: The study was a retrospective review of 100 consecutive pediatric patients, age 8–17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype. RESULTS: Overlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool. CONCLUSIONS: FD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD. |
format | Online Article Text |
id | pubmed-4960818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-49608182016-07-27 Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia Friesen, Craig A. Rosen, John M. Schurman, Jennifer V. BMC Gastroenterol Research Article BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms. METHODS: The study was a retrospective review of 100 consecutive pediatric patients, age 8–17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype. RESULTS: Overlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool. CONCLUSIONS: FD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD. BioMed Central 2016-07-25 /pmc/articles/PMC4960818/ /pubmed/27457769 http://dx.doi.org/10.1186/s12876-016-0495-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Friesen, Craig A. Rosen, John M. Schurman, Jennifer V. Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title | Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title_full | Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title_fullStr | Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title_full_unstemmed | Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title_short | Prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
title_sort | prevalence of overlap syndromes and symptoms in pediatric functional dyspepsia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960818/ https://www.ncbi.nlm.nih.gov/pubmed/27457769 http://dx.doi.org/10.1186/s12876-016-0495-3 |
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