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Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation

BACKGROUND: Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients. METHODS: The prevalence of type 1 and type 2 diabet...

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Autores principales: Kylökäs, Antti, Kaukinen, Katri, Huhtala, Heini, Collin, Pekka, Mäki, Markku, Kurppa, Kalle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960881/
https://www.ncbi.nlm.nih.gov/pubmed/27457377
http://dx.doi.org/10.1186/s12876-016-0488-2
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author Kylökäs, Antti
Kaukinen, Katri
Huhtala, Heini
Collin, Pekka
Mäki, Markku
Kurppa, Kalle
author_facet Kylökäs, Antti
Kaukinen, Katri
Huhtala, Heini
Collin, Pekka
Mäki, Markku
Kurppa, Kalle
author_sort Kylökäs, Antti
collection PubMed
description BACKGROUND: Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients. METHODS: The prevalence of type 1 and type 2 diabetes in 1358 celiac patients was compared with the population-based values. Furthermore, patients with celiac disease and concomitant type 1 or type 2 diabetes and those with celiac disease only underwent comparisons of clinical and histological features and adherence to gluten-free diet. RESULTS: The prevalence of type 1 diabetes (men/women) was 8.0 % /1.8 % in celiac patients and 0.7 % /0.3 % in the population, and that of type 2 diabetes 4.3 % /2.5 % and 4.4 % /3.0 %, respectively. Celiac patients with concomitant type 1 diabetes were younger (45 years vs 65 years and 52 years, P < 0.001) and more often screen-detected (43 % vs 13 % and 14 %, P < 0.001), had less other gastrointestinal diseases (8 % vs 40 % and 25 %, P = 0.028), more thyroidal diseases (18 % vs 16 % and 13 %, P = 0.043) and lower dietary adherence (71 % vs 95 % and 96 %, P < 0.001) compared with celiac patients with concomitant type 2 diabetes and patients with celiac disease only. Patients with concomitant type 2 diabetes had more hypercholesterolemia than the other groups (8 % vs 6 % and 4 %, P = 0.024), and both diabetes groups more hypertension (47 % and 31 % vs 15 %, P < 0.001) and coronary artery disease (29 % and 18 % vs 3 %, P < 0.001) than the patients with celiac disease only. CONCLUSIONS: Type 1 diabetes was markedly overrepresented in celiac disease, especially in men, whereas the prevalence of type 2 diabetes was comparable with the population. Concomitant type 1 or type 2 diabetes predisposes celiac patients to severe co-morbidities and type 1 diabetes also to poor dietary adherence.
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spelling pubmed-49608812016-07-27 Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation Kylökäs, Antti Kaukinen, Katri Huhtala, Heini Collin, Pekka Mäki, Markku Kurppa, Kalle BMC Gastroenterol Research Article BACKGROUND: Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients. METHODS: The prevalence of type 1 and type 2 diabetes in 1358 celiac patients was compared with the population-based values. Furthermore, patients with celiac disease and concomitant type 1 or type 2 diabetes and those with celiac disease only underwent comparisons of clinical and histological features and adherence to gluten-free diet. RESULTS: The prevalence of type 1 diabetes (men/women) was 8.0 % /1.8 % in celiac patients and 0.7 % /0.3 % in the population, and that of type 2 diabetes 4.3 % /2.5 % and 4.4 % /3.0 %, respectively. Celiac patients with concomitant type 1 diabetes were younger (45 years vs 65 years and 52 years, P < 0.001) and more often screen-detected (43 % vs 13 % and 14 %, P < 0.001), had less other gastrointestinal diseases (8 % vs 40 % and 25 %, P = 0.028), more thyroidal diseases (18 % vs 16 % and 13 %, P = 0.043) and lower dietary adherence (71 % vs 95 % and 96 %, P < 0.001) compared with celiac patients with concomitant type 2 diabetes and patients with celiac disease only. Patients with concomitant type 2 diabetes had more hypercholesterolemia than the other groups (8 % vs 6 % and 4 %, P = 0.024), and both diabetes groups more hypertension (47 % and 31 % vs 15 %, P < 0.001) and coronary artery disease (29 % and 18 % vs 3 %, P < 0.001) than the patients with celiac disease only. CONCLUSIONS: Type 1 diabetes was markedly overrepresented in celiac disease, especially in men, whereas the prevalence of type 2 diabetes was comparable with the population. Concomitant type 1 or type 2 diabetes predisposes celiac patients to severe co-morbidities and type 1 diabetes also to poor dietary adherence. BioMed Central 2016-07-25 /pmc/articles/PMC4960881/ /pubmed/27457377 http://dx.doi.org/10.1186/s12876-016-0488-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kylökäs, Antti
Kaukinen, Katri
Huhtala, Heini
Collin, Pekka
Mäki, Markku
Kurppa, Kalle
Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title_full Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title_fullStr Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title_full_unstemmed Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title_short Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
title_sort type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960881/
https://www.ncbi.nlm.nih.gov/pubmed/27457377
http://dx.doi.org/10.1186/s12876-016-0488-2
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