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The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer

BACKGROUND: Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of...

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Autores principales: Ikeya, Tetsuro, Maeda, Kiyoshi, Nagahara, Hisashi, Shibutani, Masatsune, Iseki, Yasuhito, Hirakawa, Kosei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960918/
https://www.ncbi.nlm.nih.gov/pubmed/27456345
http://dx.doi.org/10.1186/s12885-016-2577-6
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author Ikeya, Tetsuro
Maeda, Kiyoshi
Nagahara, Hisashi
Shibutani, Masatsune
Iseki, Yasuhito
Hirakawa, Kosei
author_facet Ikeya, Tetsuro
Maeda, Kiyoshi
Nagahara, Hisashi
Shibutani, Masatsune
Iseki, Yasuhito
Hirakawa, Kosei
author_sort Ikeya, Tetsuro
collection PubMed
description BACKGROUND: Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of Sema4D and PlexinB1 and the relapse-free survival in patients with colorectal cancer remains controversial. METHODS: The study population included patients who underwent surgery for colorectal cancer (n = 226). The expression of Sema4D and PlexinB1 were analyzed by immunohistochemistry in tissue of stage I, II, and III colon cancers. RESULTS: The immunohistochemical staining of colorectal cancer tissue specimens revealed that 95 (42 %) and 105 (46.4 %) of the specimens were positive for Sema4D and PlexinB1. The expression of Sema4D and PlexinB1 respectively were both found to be significantly related to stage, depth of tumor invasion, lymph node metastasis, lymphatic invasion, and venous invasion, respectively. Sixty-three patients (27.9 %) expressed both Sema4D and PlexinB1. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival (HR 1.079, CI 1.013–2.868; P = 0.044). CONCLUSION: The combination of Sema4D and PlexinB1 protein detected by immunohistochemistry was therefore useful for predicting disease recurrence in CRC patients.
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spelling pubmed-49609182016-07-27 The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer Ikeya, Tetsuro Maeda, Kiyoshi Nagahara, Hisashi Shibutani, Masatsune Iseki, Yasuhito Hirakawa, Kosei BMC Cancer Research Article BACKGROUND: Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of Sema4D and PlexinB1 and the relapse-free survival in patients with colorectal cancer remains controversial. METHODS: The study population included patients who underwent surgery for colorectal cancer (n = 226). The expression of Sema4D and PlexinB1 were analyzed by immunohistochemistry in tissue of stage I, II, and III colon cancers. RESULTS: The immunohistochemical staining of colorectal cancer tissue specimens revealed that 95 (42 %) and 105 (46.4 %) of the specimens were positive for Sema4D and PlexinB1. The expression of Sema4D and PlexinB1 respectively were both found to be significantly related to stage, depth of tumor invasion, lymph node metastasis, lymphatic invasion, and venous invasion, respectively. Sixty-three patients (27.9 %) expressed both Sema4D and PlexinB1. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival (HR 1.079, CI 1.013–2.868; P = 0.044). CONCLUSION: The combination of Sema4D and PlexinB1 protein detected by immunohistochemistry was therefore useful for predicting disease recurrence in CRC patients. BioMed Central 2016-07-25 /pmc/articles/PMC4960918/ /pubmed/27456345 http://dx.doi.org/10.1186/s12885-016-2577-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ikeya, Tetsuro
Maeda, Kiyoshi
Nagahara, Hisashi
Shibutani, Masatsune
Iseki, Yasuhito
Hirakawa, Kosei
The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title_full The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title_fullStr The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title_full_unstemmed The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title_short The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer
title_sort combined expression of semaphorin4d and plexinb1 predicts disease recurrence in colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960918/
https://www.ncbi.nlm.nih.gov/pubmed/27456345
http://dx.doi.org/10.1186/s12885-016-2577-6
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