Effect of Statins on the Mortality of Bacteremic Patients: A Systematic Review and Meta-analysis of Clinical Trials

BACKGROUND: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. AIMS: We examined the effect of statins on the mortal...

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Detalles Bibliográficos
Autores principales: Shrestha, Pragya, Poudel, Dilli R., Pathak, Ranjan, Ghimire, Sushil, Dhital, Rashmi, Aryal, Madan R., Mahmood, Maryam, Karmacharya, Paras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960934/
https://www.ncbi.nlm.nih.gov/pubmed/27500129
http://dx.doi.org/10.4103/1947-2714.185034
Descripción
Sumario:BACKGROUND: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. AIMS: We examined the effect of statins on the mortality of bacteremia patients. MATERIALS AND METHODS: Major databases were searched for the pertinent clinical trials. RESULTS: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. CONCLUSIONS: There may be a potential role of statins in similar inflammatory and infective conditions.

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