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Complete molar pregnancy in postmenopausal women
Gestational trophoblastic disease (GTD) is an abnormal proliferation of trophoblastic tissue during pregnancy. It is a disease of reproductive age, and a few cases have also been seen in women with advanced age, although it is extremely rare in postmenopausal women. Here, we describe an uncommon cas...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960948/ https://www.ncbi.nlm.nih.gov/pubmed/27499598 http://dx.doi.org/10.4103/0976-7800.185328 |
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author | Begum, Jasmina Palai, Pallavee Ghose, Seetesh |
author_facet | Begum, Jasmina Palai, Pallavee Ghose, Seetesh |
author_sort | Begum, Jasmina |
collection | PubMed |
description | Gestational trophoblastic disease (GTD) is an abnormal proliferation of trophoblastic tissue during pregnancy. It is a disease of reproductive age, and a few cases have also been seen in women with advanced age, although it is extremely rare in postmenopausal women. Here, we describe an uncommon case of complete hydatidiform mole (CHM) in a postmenopausal woman, who has presented to us with complaints of bleeding per vagina, vomiting with 22 weeks size gravid uterus. Ultrasound finding along with raised serum beta-human chorionic gonadotropin (β-HCG) 400,000 mIU/ml suggested the diagnosis of CHM. In view of postmenopausal status and future risk of postmolar gestational trophoblastic neoplasia, we performed a total abdominal hysterectomy. Uterus was 20 cm × 15 cm × 15 cm filled with cystic, grapes such as vesicles. Microscopic examination demonstrated generalized trophoblastic proliferation with hydropic degenerated villi suggested of benign CHM. Follow-up showed steady fall in serum β-HCG level and no evidence of any residual disease. A suspicion of GTD should be kept in mind while evaluating a patient with peri- or post-menopausal bleeding so that it will prevent a delay in diagnosis and treatment. |
format | Online Article Text |
id | pubmed-4960948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49609482016-08-05 Complete molar pregnancy in postmenopausal women Begum, Jasmina Palai, Pallavee Ghose, Seetesh J Midlife Health Case Report Gestational trophoblastic disease (GTD) is an abnormal proliferation of trophoblastic tissue during pregnancy. It is a disease of reproductive age, and a few cases have also been seen in women with advanced age, although it is extremely rare in postmenopausal women. Here, we describe an uncommon case of complete hydatidiform mole (CHM) in a postmenopausal woman, who has presented to us with complaints of bleeding per vagina, vomiting with 22 weeks size gravid uterus. Ultrasound finding along with raised serum beta-human chorionic gonadotropin (β-HCG) 400,000 mIU/ml suggested the diagnosis of CHM. In view of postmenopausal status and future risk of postmolar gestational trophoblastic neoplasia, we performed a total abdominal hysterectomy. Uterus was 20 cm × 15 cm × 15 cm filled with cystic, grapes such as vesicles. Microscopic examination demonstrated generalized trophoblastic proliferation with hydropic degenerated villi suggested of benign CHM. Follow-up showed steady fall in serum β-HCG level and no evidence of any residual disease. A suspicion of GTD should be kept in mind while evaluating a patient with peri- or post-menopausal bleeding so that it will prevent a delay in diagnosis and treatment. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4960948/ /pubmed/27499598 http://dx.doi.org/10.4103/0976-7800.185328 Text en Copyright: © 2016 Journal of Mid-life Health http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Begum, Jasmina Palai, Pallavee Ghose, Seetesh Complete molar pregnancy in postmenopausal women |
title | Complete molar pregnancy in postmenopausal women |
title_full | Complete molar pregnancy in postmenopausal women |
title_fullStr | Complete molar pregnancy in postmenopausal women |
title_full_unstemmed | Complete molar pregnancy in postmenopausal women |
title_short | Complete molar pregnancy in postmenopausal women |
title_sort | complete molar pregnancy in postmenopausal women |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960948/ https://www.ncbi.nlm.nih.gov/pubmed/27499598 http://dx.doi.org/10.4103/0976-7800.185328 |
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