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SoxD Transcription Factors: Multifaceted Players of Neural Development

SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in mult...

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Autores principales: Ji, Eun Hye, Kim, Jaesang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961098/
https://www.ncbi.nlm.nih.gov/pubmed/27426080
http://dx.doi.org/10.15283/ijsc.2016.9.1.3
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author Ji, Eun Hye
Kim, Jaesang
author_facet Ji, Eun Hye
Kim, Jaesang
author_sort Ji, Eun Hye
collection PubMed
description SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter-specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.
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spelling pubmed-49610982016-08-01 SoxD Transcription Factors: Multifaceted Players of Neural Development Ji, Eun Hye Kim, Jaesang Int J Stem Cells Review Article SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter-specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development. Korean Society for Stem Cell Research 2016-05 /pmc/articles/PMC4961098/ /pubmed/27426080 http://dx.doi.org/10.15283/ijsc.2016.9.1.3 Text en Copyright ©2016, Korean Society for Stem Cell Research This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ji, Eun Hye
Kim, Jaesang
SoxD Transcription Factors: Multifaceted Players of Neural Development
title SoxD Transcription Factors: Multifaceted Players of Neural Development
title_full SoxD Transcription Factors: Multifaceted Players of Neural Development
title_fullStr SoxD Transcription Factors: Multifaceted Players of Neural Development
title_full_unstemmed SoxD Transcription Factors: Multifaceted Players of Neural Development
title_short SoxD Transcription Factors: Multifaceted Players of Neural Development
title_sort soxd transcription factors: multifaceted players of neural development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961098/
https://www.ncbi.nlm.nih.gov/pubmed/27426080
http://dx.doi.org/10.15283/ijsc.2016.9.1.3
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