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The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa
Correlations between angiotensin-converting enzyme (ACE) genotype (I/I, I/D, D/D), disease severity at baseline and response to enzyme replacement therapy (ERT) were assessed in the Pompe disease Late-Onset Treatment Study (LOTS). No correlations were observed between ACE genotype and disease severi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961277/ https://www.ncbi.nlm.nih.gov/pubmed/27489778 http://dx.doi.org/10.1016/j.ymgmr.2016.07.005 |
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author | Baek, Rena C. Palmer, Rachel Pomponio, Robert J. Lu, Yuefeng Ma, Xiwen McVie-Wylie, Alison J. |
author_facet | Baek, Rena C. Palmer, Rachel Pomponio, Robert J. Lu, Yuefeng Ma, Xiwen McVie-Wylie, Alison J. |
author_sort | Baek, Rena C. |
collection | PubMed |
description | Correlations between angiotensin-converting enzyme (ACE) genotype (I/I, I/D, D/D), disease severity at baseline and response to enzyme replacement therapy (ERT) were assessed in the Pompe disease Late-Onset Treatment Study (LOTS). No correlations were observed between ACE genotype and disease severity at baseline. However, D/D patients appeared to have a reduced response to alglucosidase alfa treatment than I/I or I/D patients, suggesting that ACE polymorphisms may influence the response to alglucosidase alfa treatment and warrants further investigation. |
format | Online Article Text |
id | pubmed-4961277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49612772016-08-03 The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa Baek, Rena C. Palmer, Rachel Pomponio, Robert J. Lu, Yuefeng Ma, Xiwen McVie-Wylie, Alison J. Mol Genet Metab Rep Short Communication Correlations between angiotensin-converting enzyme (ACE) genotype (I/I, I/D, D/D), disease severity at baseline and response to enzyme replacement therapy (ERT) were assessed in the Pompe disease Late-Onset Treatment Study (LOTS). No correlations were observed between ACE genotype and disease severity at baseline. However, D/D patients appeared to have a reduced response to alglucosidase alfa treatment than I/I or I/D patients, suggesting that ACE polymorphisms may influence the response to alglucosidase alfa treatment and warrants further investigation. Elsevier 2016-07-22 /pmc/articles/PMC4961277/ /pubmed/27489778 http://dx.doi.org/10.1016/j.ymgmr.2016.07.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Communication Baek, Rena C. Palmer, Rachel Pomponio, Robert J. Lu, Yuefeng Ma, Xiwen McVie-Wylie, Alison J. The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title | The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title_full | The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title_fullStr | The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title_full_unstemmed | The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title_short | The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa |
title_sort | influence of a polymorphism in the gene encoding angiotensin converting enzyme (ace) on treatment outcomes in late-onset pompe patients receiving alglucosidase alfa |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961277/ https://www.ncbi.nlm.nih.gov/pubmed/27489778 http://dx.doi.org/10.1016/j.ymgmr.2016.07.005 |
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