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Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer’s-Like Pathological Features in Mice

Amyloid precursor protein (APP) is cleaved by gamma-secretase to simultaneously generate amyloid beta (Aβ) and APP Intracellular Domain (AICD) peptides. Aβ plays a pivotal role in Alzheimer’s disease (AD) pathogenesis but recent studies suggest that amyloid-independent mechanisms also contribute to...

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Detalles Bibliográficos
Autores principales:	Ghosal, Kaushik, Fan, Qingyuan, Dawson, Hana N., Pimplikar, Sanjay W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961442/ https://www.ncbi.nlm.nih.gov/pubmed/27459671 http://dx.doi.org/10.1371/journal.pone.0159435

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