Decoding RAS isoform and codon-specific signalling

RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations rema...

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Detalles Bibliográficos
Autores principales: Newlaczyl, Anna U., Hood, Fiona E., Coulson, Judy M., Prior, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Biochemical Society Focused Meetings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961500/
https://www.ncbi.nlm.nih.gov/pubmed/25109951
http://dx.doi.org/10.1042/BST20140057
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author Newlaczyl, Anna U.
Hood, Fiona E.
Coulson, Judy M.
Prior, Ian A.
author_facet Newlaczyl, Anna U.
Hood, Fiona E.
Coulson, Judy M.
Prior, Ian A.
author_sort Newlaczyl, Anna U.
collection PubMed
description RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.
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spelling pubmed-49615002016-07-27 Decoding RAS isoform and codon-specific signalling Newlaczyl, Anna U. Hood, Fiona E. Coulson, Judy M. Prior, Ian A. Biochem Soc Trans Biochemical Society Focused Meetings RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms. Portland Press Ltd. 2014-08-11 2014-08-01 /pmc/articles/PMC4961500/ /pubmed/25109951 http://dx.doi.org/10.1042/BST20140057 Text en © 2014 The Author(s) http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biochemical Society Focused Meetings
Newlaczyl, Anna U.
Hood, Fiona E.
Coulson, Judy M.
Prior, Ian A.
Decoding RAS isoform and codon-specific signalling
title Decoding RAS isoform and codon-specific signalling
title_full Decoding RAS isoform and codon-specific signalling
title_fullStr Decoding RAS isoform and codon-specific signalling
title_full_unstemmed Decoding RAS isoform and codon-specific signalling
title_short Decoding RAS isoform and codon-specific signalling
title_sort decoding ras isoform and codon-specific signalling
topic Biochemical Society Focused Meetings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961500/
https://www.ncbi.nlm.nih.gov/pubmed/25109951
http://dx.doi.org/10.1042/BST20140057
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