Bidirectional prefrontal-hippocampal interactions support context-guided memory

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Upon context entry, functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex. Conversely,...

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Detalles Bibliográficos
Autores principales: Place, Ryan, Farovik, Anja, Brockmann, Marco, Eichenbaum, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961615/
https://www.ncbi.nlm.nih.gov/pubmed/27322417
http://dx.doi.org/10.1038/nn.4327
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author Place, Ryan
Farovik, Anja
Brockmann, Marco
Eichenbaum, Howard
author_facet Place, Ryan
Farovik, Anja
Brockmann, Marco
Eichenbaum, Howard
author_sort Place, Ryan
collection PubMed
description We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Upon context entry, functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.
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spelling pubmed-49616152016-12-20 Bidirectional prefrontal-hippocampal interactions support context-guided memory Place, Ryan Farovik, Anja Brockmann, Marco Eichenbaum, Howard Nat Neurosci Article We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Upon context entry, functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations. 2016-06-20 2016-08 /pmc/articles/PMC4961615/ /pubmed/27322417 http://dx.doi.org/10.1038/nn.4327 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Place, Ryan
Farovik, Anja
Brockmann, Marco
Eichenbaum, Howard
Bidirectional prefrontal-hippocampal interactions support context-guided memory
title Bidirectional prefrontal-hippocampal interactions support context-guided memory
title_full Bidirectional prefrontal-hippocampal interactions support context-guided memory
title_fullStr Bidirectional prefrontal-hippocampal interactions support context-guided memory
title_full_unstemmed Bidirectional prefrontal-hippocampal interactions support context-guided memory
title_short Bidirectional prefrontal-hippocampal interactions support context-guided memory
title_sort bidirectional prefrontal-hippocampal interactions support context-guided memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961615/
https://www.ncbi.nlm.nih.gov/pubmed/27322417
http://dx.doi.org/10.1038/nn.4327
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AT brockmannmarco bidirectionalprefrontalhippocampalinteractionssupportcontextguidedmemory
AT eichenbaumhoward bidirectionalprefrontalhippocampalinteractionssupportcontextguidedmemory

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