Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Light-regulated drugs allow remotely photoswitching biological activity and enable plausible therapies based on small molecules. However, only freely diffusible photochromic ligands have been shown to work directly in endogenous receptors and methods for covalent attachment depend on genetic manipul...

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Detalles Bibliográficos
Autores principales: Izquierdo-Serra, Mercè, Bautista-Barrufet, Antoni, Trapero, Ana, Garrido-Charles, Aida, Díaz-Tahoces, Ariadna, Camarero, Nuria, Pittolo, Silvia, Valbuena, Sergio, Pérez-Jiménez, Ariadna, Gay, Marina, García-Moll, Alejandro, Rodríguez-Escrich, Carles, Lerma, Juan, de la Villa, Pedro, Fernández, Eduardo, Pericàs, Miquel À, Llebaria, Amadeu, Gorostiza, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961765/
https://www.ncbi.nlm.nih.gov/pubmed/27436051
http://dx.doi.org/10.1038/ncomms12221

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