Simultaneous Inhibition of PGE(2) and PGI(2) Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

Prostaglandin E(2) (PGE(2)) is well known as a mediator of inflammatory symptoms such as fever, arthritis, and inflammatory pain. In the present study, we evaluated the analgesic effect of our selective PGE(2) synthesis inhibitor, compound I, 2-methyl-2-[cis-4-([1-(6-methyl-3-phenylquinolin-2-yl)pip...

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Detalles Bibliográficos
Autores principales: Sugita, Ryusuke, Kuwabara, Harumi, Kubota, Kazufumi, Sugimoto, Kotaro, Kiho, Toshihiro, Tengeiji, Atsushi, Kawakami, Katsuhiro, Shimada, Kohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961812/
https://www.ncbi.nlm.nih.gov/pubmed/27478311
http://dx.doi.org/10.1155/2016/9847840

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