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Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions are modulated by thrombin cleavage generating...

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Detalles Bibliográficos
Autores principales:	Boggio, Elena, Dianzani, Chiara, Gigliotti, Casimiro Luca, Soluri, Maria Felicia, Clemente, Nausicaa, Cappellano, Giuseppe, Toth, Erika, Raineri, Davide, Ferrara, Benedetta, Comi, Cristoforo, Dianzani, Umberto, Chiocchetti, Annalisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961817/ https://www.ncbi.nlm.nih.gov/pubmed/27478856 http://dx.doi.org/10.1155/2016/9345495

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