A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Surface galectin has been shown to contribute to dysfunctions of human tumour-infiltrating lymphocytes (TILs). We show here that galectin-covered CD8 TILs produce normal amounts of intracellular cytokines, but fail to secrete them because of defective actin rearrangements at the synapse. The non-sec...

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Detalles Bibliográficos
Autores principales: Petit, Anne-Elisabeth, Demotte, Nathalie, Scheid, Benoît, Wildmann, Claude, Bigirimana, René, Gordon-Alonso, Monica, Carrasco, Javier, Valitutti, Salvatore, Godelaine, Danièle, van der Bruggen, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961845/
https://www.ncbi.nlm.nih.gov/pubmed/27447355
http://dx.doi.org/10.1038/ncomms12242

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