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Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of kinetically and conformationally stable enzyme for structural characterization ha...

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Detalles Bibliográficos
Autores principales:	Bezem, Maria T., Baumann, Anne, Skjærven, Lars, Meyer, Romain, Kursula, Petri, Martinez, Aurora, Flydal, Marte I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961952/ https://www.ncbi.nlm.nih.gov/pubmed/27462005 http://dx.doi.org/10.1038/srep30390

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