Cargando…
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles
Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as replication and transcription. However, our understanding of how the cellular machinery deals with unusual DNA structures such as G-quadruple...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962001/ https://www.ncbi.nlm.nih.gov/pubmed/27376332 http://dx.doi.org/10.3390/genes7070031 |
_version_ | 1782444746422091776 |
---|---|
author | Bharti, Sanjay Kumar Awate, Sanket Banerjee, Taraswi Brosh, Robert M. |
author_facet | Bharti, Sanjay Kumar Awate, Sanket Banerjee, Taraswi Brosh, Robert M. |
author_sort | Bharti, Sanjay Kumar |
collection | PubMed |
description | Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as replication and transcription. However, our understanding of how the cellular machinery deals with unusual DNA structures such as G-quadruplexes (G4), triplexes, or hairpins is only beginning to emerge. New advances in the field implicate a direct role of the Fanconi Anemia Group J (FANCJ) helicase, which is linked to a hereditary chromosomal instability disorder and important for cancer suppression, in replication past unusual DNA obstacles. This work sets the stage for significant progress in dissecting the molecular mechanisms whereby replication perturbation by abnormal DNA structures leads to genomic instability. In this review, we focus on FANCJ and its role to enable efficient DNA replication when the fork encounters vastly abundant naturally occurring DNA obstacles, which may have implications for targeting rapidly dividing cancer cells. |
format | Online Article Text |
id | pubmed-4962001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49620012016-08-01 Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles Bharti, Sanjay Kumar Awate, Sanket Banerjee, Taraswi Brosh, Robert M. Genes (Basel) Review Mounting evidence indicates that alternate DNA structures, which deviate from normal double helical DNA, form in vivo and influence cellular processes such as replication and transcription. However, our understanding of how the cellular machinery deals with unusual DNA structures such as G-quadruplexes (G4), triplexes, or hairpins is only beginning to emerge. New advances in the field implicate a direct role of the Fanconi Anemia Group J (FANCJ) helicase, which is linked to a hereditary chromosomal instability disorder and important for cancer suppression, in replication past unusual DNA obstacles. This work sets the stage for significant progress in dissecting the molecular mechanisms whereby replication perturbation by abnormal DNA structures leads to genomic instability. In this review, we focus on FANCJ and its role to enable efficient DNA replication when the fork encounters vastly abundant naturally occurring DNA obstacles, which may have implications for targeting rapidly dividing cancer cells. MDPI 2016-07-01 /pmc/articles/PMC4962001/ /pubmed/27376332 http://dx.doi.org/10.3390/genes7070031 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bharti, Sanjay Kumar Awate, Sanket Banerjee, Taraswi Brosh, Robert M. Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title | Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title_full | Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title_fullStr | Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title_full_unstemmed | Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title_short | Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles |
title_sort | getting ready for the dance: fancj irons out dna wrinkles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962001/ https://www.ncbi.nlm.nih.gov/pubmed/27376332 http://dx.doi.org/10.3390/genes7070031 |
work_keys_str_mv | AT bhartisanjaykumar gettingreadyforthedancefancjironsoutdnawrinkles AT awatesanket gettingreadyforthedancefancjironsoutdnawrinkles AT banerjeetaraswi gettingreadyforthedancefancjironsoutdnawrinkles AT broshrobertm gettingreadyforthedancefancjironsoutdnawrinkles |