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Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5′ Adducts

Topoisomerase 2 (Top2) is an essential enzyme responsible for manipulating DNA topology during replication, transcription, chromosome organization and chromosome segregation. It acts by nicking both strands of DNA and then passes another DNA molecule through the break. The 5′ end of each nick is cov...

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Detalles Bibliográficos
Autores principales:	Yan, Hong, Tammaro, Margaret, Liao, Shuren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962002/ https://www.ncbi.nlm.nih.gov/pubmed/27376333 http://dx.doi.org/10.3390/genes7070032

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