Cargando…

Willing to Be Involved in Cancer

Genome sequencing is now a common procedure, but prior to this, screening experiments using protein baits was one of the routinely used methods that, occasionally, allowed the identification of new gene products. One such experiment uncovered the gene product called willin/human Expanded/FRMD6. Init...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunn-Moore, Frank J., Tilston-Lünel, Andrew M., Reynolds, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962007/
https://www.ncbi.nlm.nih.gov/pubmed/27438856
http://dx.doi.org/10.3390/genes7070037
_version_ 1782444747797823488
author Gunn-Moore, Frank J.
Tilston-Lünel, Andrew M.
Reynolds, Paul A.
author_facet Gunn-Moore, Frank J.
Tilston-Lünel, Andrew M.
Reynolds, Paul A.
author_sort Gunn-Moore, Frank J.
collection PubMed
description Genome sequencing is now a common procedure, but prior to this, screening experiments using protein baits was one of the routinely used methods that, occasionally, allowed the identification of new gene products. One such experiment uncovered the gene product called willin/human Expanded/FRMD6. Initial characterization studies found that willin bound phospholipids and was strongly co-localised with actin. However, subsequently, willin was found to be the closest human sequence homologue of the Drosophila protein Expanded (Ex), sharing 60% homology with the Ex FERM domain. This in turn suggested, and then was proven that willin could activate the Hippo signalling pathway. This review describes the increasing body of knowledge about the actions of willin in a number of cellular functions related to cancer. However, like many gene products involved in aspects of cell signalling, a convincing direct role for willin in cancer remains tantalisingly elusive, at present.
format Online
Article
Text
id pubmed-4962007
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-49620072016-08-01 Willing to Be Involved in Cancer Gunn-Moore, Frank J. Tilston-Lünel, Andrew M. Reynolds, Paul A. Genes (Basel) Review Genome sequencing is now a common procedure, but prior to this, screening experiments using protein baits was one of the routinely used methods that, occasionally, allowed the identification of new gene products. One such experiment uncovered the gene product called willin/human Expanded/FRMD6. Initial characterization studies found that willin bound phospholipids and was strongly co-localised with actin. However, subsequently, willin was found to be the closest human sequence homologue of the Drosophila protein Expanded (Ex), sharing 60% homology with the Ex FERM domain. This in turn suggested, and then was proven that willin could activate the Hippo signalling pathway. This review describes the increasing body of knowledge about the actions of willin in a number of cellular functions related to cancer. However, like many gene products involved in aspects of cell signalling, a convincing direct role for willin in cancer remains tantalisingly elusive, at present. MDPI 2016-07-18 /pmc/articles/PMC4962007/ /pubmed/27438856 http://dx.doi.org/10.3390/genes7070037 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gunn-Moore, Frank J.
Tilston-Lünel, Andrew M.
Reynolds, Paul A.
Willing to Be Involved in Cancer
title Willing to Be Involved in Cancer
title_full Willing to Be Involved in Cancer
title_fullStr Willing to Be Involved in Cancer
title_full_unstemmed Willing to Be Involved in Cancer
title_short Willing to Be Involved in Cancer
title_sort willing to be involved in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962007/
https://www.ncbi.nlm.nih.gov/pubmed/27438856
http://dx.doi.org/10.3390/genes7070037
work_keys_str_mv AT gunnmoorefrankj willingtobeinvolvedincancer
AT tilstonlunelandrewm willingtobeinvolvedincancer
AT reynoldspaula willingtobeinvolvedincancer