Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107

Three new meroterpenoids, named austalides S-U (1–3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4–14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, a...

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Autores principales: Peng, Jixing, Zhang, Xiaomin, Wang, Wei, Zhu, Tianjiao, Gu, Qianqun, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962021/
https://www.ncbi.nlm.nih.gov/pubmed/27428982
http://dx.doi.org/10.3390/md14070131
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author Peng, Jixing
Zhang, Xiaomin
Wang, Wei
Zhu, Tianjiao
Gu, Qianqun
Li, Dehai
author_facet Peng, Jixing
Zhang, Xiaomin
Wang, Wei
Zhu, Tianjiao
Gu, Qianqun
Li, Dehai
author_sort Peng, Jixing
collection PubMed
description Three new meroterpenoids, named austalides S-U (1–3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4–14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC(50) values of 90 and 99 μM, respectively.
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spelling pubmed-49620212016-08-01 Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107 Peng, Jixing Zhang, Xiaomin Wang, Wei Zhu, Tianjiao Gu, Qianqun Li, Dehai Mar Drugs Article Three new meroterpenoids, named austalides S-U (1–3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4–14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC(50) values of 90 and 99 μM, respectively. MDPI 2016-07-14 /pmc/articles/PMC4962021/ /pubmed/27428982 http://dx.doi.org/10.3390/md14070131 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peng, Jixing
Zhang, Xiaomin
Wang, Wei
Zhu, Tianjiao
Gu, Qianqun
Li, Dehai
Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title_full Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title_fullStr Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title_full_unstemmed Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title_short Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107
title_sort austalides s-u, new meroterpenoids from the sponge-derived fungus aspergillus aureolatus hdn14-107
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962021/
https://www.ncbi.nlm.nih.gov/pubmed/27428982
http://dx.doi.org/10.3390/md14070131
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