Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum

Six new chamigrane sesquiterpenes, merulinols A‒F (1‒6), and four known metabolites (7‒10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed...

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Autores principales: Choodej, Siwattra, Teerawatananond, Thapong, Mitsunaga, Tohru, Pudhom, Khanitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962022/
https://www.ncbi.nlm.nih.gov/pubmed/27428984
http://dx.doi.org/10.3390/md14070132
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author Choodej, Siwattra
Teerawatananond, Thapong
Mitsunaga, Tohru
Pudhom, Khanitha
author_facet Choodej, Siwattra
Teerawatananond, Thapong
Mitsunaga, Tohru
Pudhom, Khanitha
author_sort Choodej, Siwattra
collection PubMed
description Six new chamigrane sesquiterpenes, merulinols A‒F (1‒6), and four known metabolites (7‒10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC(50) values of 35.0 and 25.3 μM, respectively.
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spelling pubmed-49620222016-08-01 Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum Choodej, Siwattra Teerawatananond, Thapong Mitsunaga, Tohru Pudhom, Khanitha Mar Drugs Article Six new chamigrane sesquiterpenes, merulinols A‒F (1‒6), and four known metabolites (7‒10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC(50) values of 35.0 and 25.3 μM, respectively. MDPI 2016-07-15 /pmc/articles/PMC4962022/ /pubmed/27428984 http://dx.doi.org/10.3390/md14070132 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choodej, Siwattra
Teerawatananond, Thapong
Mitsunaga, Tohru
Pudhom, Khanitha
Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title_full Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title_fullStr Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title_full_unstemmed Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title_short Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum
title_sort chamigrane sesquiterpenes from a basidiomycetous endophytic fungus xg8d associated with thai mangrove xylocarpus granatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962022/
https://www.ncbi.nlm.nih.gov/pubmed/27428984
http://dx.doi.org/10.3390/md14070132
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