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From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics
Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine bi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962027/ https://www.ncbi.nlm.nih.gov/pubmed/27455283 http://dx.doi.org/10.3390/md14070137 |
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author | Silber, Johanna Kramer, Annemarie Labes, Antje Tasdemir, Deniz |
author_facet | Silber, Johanna Kramer, Annemarie Labes, Antje Tasdemir, Deniz |
author_sort | Silber, Johanna |
collection | PubMed |
description | Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics. |
format | Online Article Text |
id | pubmed-4962027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49620272016-08-01 From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics Silber, Johanna Kramer, Annemarie Labes, Antje Tasdemir, Deniz Mar Drugs Review Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics. MDPI 2016-07-21 /pmc/articles/PMC4962027/ /pubmed/27455283 http://dx.doi.org/10.3390/md14070137 Text en © 2016 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silber, Johanna Kramer, Annemarie Labes, Antje Tasdemir, Deniz From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title | From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title_full | From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title_fullStr | From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title_full_unstemmed | From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title_short | From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics |
title_sort | from discovery to production: biotechnology of marine fungi for the production of new antibiotics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962027/ https://www.ncbi.nlm.nih.gov/pubmed/27455283 http://dx.doi.org/10.3390/md14070137 |
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