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Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP)
Children’s exposure assessment is a key input into epidemiology studies, risk assessment and source apportionment. The goals of this article are to describe a methodology for children’s exposure assessment that can be used for these purposes and to apply the methodology to source apportionment for t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962211/ https://www.ncbi.nlm.nih.gov/pubmed/27376320 http://dx.doi.org/10.3390/ijerph13070670 |
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author | Ginsberg, Gary Ginsberg, Justine Foos, Brenda |
author_facet | Ginsberg, Gary Ginsberg, Justine Foos, Brenda |
author_sort | Ginsberg, Gary |
collection | PubMed |
description | Children’s exposure assessment is a key input into epidemiology studies, risk assessment and source apportionment. The goals of this article are to describe a methodology for children’s exposure assessment that can be used for these purposes and to apply the methodology to source apportionment for the case study chemical, diethylhexylphthalate (DEHP). A key feature is the comparison of total (aggregate) exposure calculated via a pathways approach to that derived from a biomonitoring approach. The 4-step methodology and its results for DEHP are: (1) Prioritization of life stages and exposure pathways, with pregnancy, breast-fed infants, and toddlers the focus of the case study and pathways selected that are relevant to these groups; (2) Estimation of pathway-specific exposures by life stage wherein diet was found to be the largest contributor for pregnant women, breast milk and mouthing behavior for the nursing infant and diet, house dust, and mouthing for toddlers; (3) Comparison of aggregate exposure by pathways vs biomonitoring-based approaches wherein good concordance was found for toddlers and pregnant women providing confidence in the exposure assessment; (4) Source apportionment in which DEHP presence in foods, children’s products, consumer products and the built environment are discussed with respect to early life mouthing, house dust and dietary exposure. A potential fifth step of the method involves the calculation of exposure doses for risk assessment which is described but outside the scope for the current case study. In summary, the methodology has been used to synthesize the available information to identify key sources of early life exposure to DEHP. |
format | Online Article Text |
id | pubmed-4962211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49622112016-08-01 Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) Ginsberg, Gary Ginsberg, Justine Foos, Brenda Int J Environ Res Public Health Review Children’s exposure assessment is a key input into epidemiology studies, risk assessment and source apportionment. The goals of this article are to describe a methodology for children’s exposure assessment that can be used for these purposes and to apply the methodology to source apportionment for the case study chemical, diethylhexylphthalate (DEHP). A key feature is the comparison of total (aggregate) exposure calculated via a pathways approach to that derived from a biomonitoring approach. The 4-step methodology and its results for DEHP are: (1) Prioritization of life stages and exposure pathways, with pregnancy, breast-fed infants, and toddlers the focus of the case study and pathways selected that are relevant to these groups; (2) Estimation of pathway-specific exposures by life stage wherein diet was found to be the largest contributor for pregnant women, breast milk and mouthing behavior for the nursing infant and diet, house dust, and mouthing for toddlers; (3) Comparison of aggregate exposure by pathways vs biomonitoring-based approaches wherein good concordance was found for toddlers and pregnant women providing confidence in the exposure assessment; (4) Source apportionment in which DEHP presence in foods, children’s products, consumer products and the built environment are discussed with respect to early life mouthing, house dust and dietary exposure. A potential fifth step of the method involves the calculation of exposure doses for risk assessment which is described but outside the scope for the current case study. In summary, the methodology has been used to synthesize the available information to identify key sources of early life exposure to DEHP. MDPI 2016-07-01 2016-07 /pmc/articles/PMC4962211/ /pubmed/27376320 http://dx.doi.org/10.3390/ijerph13070670 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ginsberg, Gary Ginsberg, Justine Foos, Brenda Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title | Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title_full | Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title_fullStr | Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title_full_unstemmed | Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title_short | Approaches to Children’s Exposure Assessment: Case Study with Diethylhexylphthalate (DEHP) |
title_sort | approaches to children’s exposure assessment: case study with diethylhexylphthalate (dehp) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962211/ https://www.ncbi.nlm.nih.gov/pubmed/27376320 http://dx.doi.org/10.3390/ijerph13070670 |
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