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Regenerating the liver: not so simple after all?
Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year. Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962288/ https://www.ncbi.nlm.nih.gov/pubmed/27508069 http://dx.doi.org/10.12688/f1000research.8827.1 |
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author | Alison, Malcolm R. Lin, Wey-Ran |
author_facet | Alison, Malcolm R. Lin, Wey-Ran |
author_sort | Alison, Malcolm R. |
collection | PubMed |
description | Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year. Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerative re-population, but recent murine studies have brought greater complexity to the issue. Although periportal hepatocytes are still considered pre-eminent in the response to 2/3 PH, new studies suggest that normal homeostatic renewal is driven by pericentral hepatocytes under the control of Wnts, while pericentral injury provokes the clonal expansion of a subpopulation of periportal hepatocytes expressing low levels of biliary duct genes such as Sox9 and osteopontin. Furthermore, some clarity has been given to the debate on the ability of biliary-derived hepatic progenitor cells to generate physiologically meaningful numbers of hepatocytes in injury models, demonstrating that under appropriate circumstances these cells can re-populate the whole liver. |
format | Online Article Text |
id | pubmed-4962288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-49622882016-08-08 Regenerating the liver: not so simple after all? Alison, Malcolm R. Lin, Wey-Ran F1000Res Review Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year. Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerative re-population, but recent murine studies have brought greater complexity to the issue. Although periportal hepatocytes are still considered pre-eminent in the response to 2/3 PH, new studies suggest that normal homeostatic renewal is driven by pericentral hepatocytes under the control of Wnts, while pericentral injury provokes the clonal expansion of a subpopulation of periportal hepatocytes expressing low levels of biliary duct genes such as Sox9 and osteopontin. Furthermore, some clarity has been given to the debate on the ability of biliary-derived hepatic progenitor cells to generate physiologically meaningful numbers of hepatocytes in injury models, demonstrating that under appropriate circumstances these cells can re-populate the whole liver. F1000Research 2016-07-26 /pmc/articles/PMC4962288/ /pubmed/27508069 http://dx.doi.org/10.12688/f1000research.8827.1 Text en Copyright: © 2016 Alison MR and Lin WR http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Alison, Malcolm R. Lin, Wey-Ran Regenerating the liver: not so simple after all? |
title | Regenerating the liver: not so simple after all? |
title_full | Regenerating the liver: not so simple after all? |
title_fullStr | Regenerating the liver: not so simple after all? |
title_full_unstemmed | Regenerating the liver: not so simple after all? |
title_short | Regenerating the liver: not so simple after all? |
title_sort | regenerating the liver: not so simple after all? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962288/ https://www.ncbi.nlm.nih.gov/pubmed/27508069 http://dx.doi.org/10.12688/f1000research.8827.1 |
work_keys_str_mv | AT alisonmalcolmr regeneratingthelivernotsosimpleafterall AT linweyran regeneratingthelivernotsosimpleafterall |