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Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson’s disease etiology

Recent genome-wide association studies (GWAS) of Parkinson’s disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrog...

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Detalles Bibliográficos
Autores principales: Coetzee, Simon G., Pierce, Steven, Brundin, Patrik, Brundin, Lena, Hazelett, Dennis J., Coetzee, Gerhard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962314/
https://www.ncbi.nlm.nih.gov/pubmed/27461410
http://dx.doi.org/10.1038/srep30509