Cargando…

An exome array study of the plasma metabolome

The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,52...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rhee, Eugene P., Yang, Qiong, Yu, Bing, Liu, Xuan, Cheng, Susan, Deik, Amy, Pierce, Kerry A., Bullock, Kevin, Ho, Jennifer E., Levy, Daniel, Florez, Jose C., Kathiresan, Sek, Larson, Martin G., Vasan, Ramachandran S., Clish, Clary B., Wang, Thomas J., Boerwinkle, Eric, O'Donnell, Christopher J., Gerszten, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962516/ https://www.ncbi.nlm.nih.gov/pubmed/27453504 http://dx.doi.org/10.1038/ncomms12360

Ejemplares similares

EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression
por: Xu, Yu-Xin, et al.
Publicado: (2020)

Distinct Metabolomic Signatures Are Associated with Longevity in Humans
por: Cheng, Susan, et al.
Publicado: (2015)

Metabolite Profiles During Oral Glucose Challenge
por: Ho, Jennifer E., et al.
Publicado: (2013)

A Plasma Long‐Chain Acylcarnitine Predicts Cardiovascular Mortality in Incident Dialysis Patients
por: Kalim, Sahir, et al.
Publicado: (2013)

Portal Venous Metabolite Profiling After RYGB in Male Rats Highlights Changes in Gut-Liver Axis
por: Stefater, Margaret A, et al.
Publicado: (2020)

Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes
por: Ho, Jennifer E., et al.
Publicado: (2016)

Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community
por: Gonzalez Izundegui, Daniel, et al.
Publicado: (2022)

Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension
por: Rhee, Eugene P., et al.
Publicado: (2015)

Cross-sectional examination of metabolites and metabolic phenotypes in uremia
por: Kalim, Sahir, et al.
Publicado: (2015)

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
por: Walford, Geoffrey A., et al.
Publicado: (2016)

Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study
por: Walker, Maura E., et al.
Publicado: (2020)

Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study
por: Corlin, Laura, et al.
Publicado: (2020)

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions
por: Bihlmeyer, Nathan A., et al.
Publicado: (2021)

Dimethylglycine Deficiency and the Development of Diabetes
por: Magnusson, Martin, et al.
Publicado: (2015)

Metabolomic signatures of cardiac remodelling and heart failure risk in the community
por: Andersson, Charlotte, et al.
Publicado: (2020)

Metabolomic markers of glucose regulation after a lifestyle intervention in prediabetes
por: Sevilla-Gonzalez, Magdalena del Rocio, et al.
Publicado: (2022)

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
por: Vasan, Ramachandran S, et al.
Publicado: (2007)

Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study
por: Chen, Ming-Huei, et al.
Publicado: (2012)

Hdh(Q111) Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation
por: Carroll, Jeffrey B., et al.
Publicado: (2015)

Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
por: Levy, Daniel, et al.
Publicado: (2006)

Metabolomics: an emerging but powerful tool for precision medicine
por: Clish, Clary B.
Publicado: (2015)

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation
por: Avanesov, Andrei S, et al.
Publicado: (2014)

ADP Platelet Hyperreactivity Predicts Cardiovascular Disease in the FHS (Framingham Heart Study)
por: Puurunen, Marja K., et al.
Publicado: (2018)

Exome Array Analysis of Susceptibility to Pneumococcal Meningitis
por: Kloek, Anne T., et al.
Publicado: (2016)

Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium
por: Grove, Megan L., et al.
Publicado: (2013)

Circulating Galectin‐3 Is Associated With Cardiometabolic Disease in the Community
por: Nayor, Matthew, et al.
Publicado: (2015)

Exome arrays capture polygenic rare variant contributions to schizophrenia
por: Richards, A. L., et al.
Publicado: (2016)

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
por: Zhou, Wen, et al.
Publicado: (2023)

Intrapersonal Stability of Plasma Metabolomic Profiles over 10 Years among Women
por: Zeleznik, Oana A., et al.
Publicado: (2022)

Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
por: Yang, Qiong, et al.
Publicado: (2007)

Metabolomic Analysis of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
por: McClain, Kathleen M., et al.
Publicado: (2022)

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
por: Soto, Marion, et al.
Publicado: (2018)

Capturing variation in Lens (Fabaceae): Development and utility of an exome capture array for lentil
por: Ogutcen, Ezgi, et al.
Publicado: (2018)

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
por: Wang, Qingbo, et al.
Publicado: (2020)

Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study
por: Portilla-Fernandez, Eliana, et al.
Publicado: (2022)

Exome sequencing and complex disease: practical aspects of rare variant association studies
por: Do, Ron, et al.
Publicado: (2012)

Proteomics Profiling and Risk of New‐Onset Atrial Fibrillation: Framingham Heart Study
por: Ko, Darae, et al.
Publicado: (2019)

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
por: Mitchell, Wayne, et al.
Publicado: (2023)

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
por: Shindyapina, Anastasia V., et al.
Publicado: (2022)

Measuring Coverage and Accuracy of Whole Exome Sequencing in Clinical Context
por: Kong, Sek Won, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ue1n5lar0bvsc57lu10khsea67