Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

BACKGROUND: Increased reports of human infections have led fasciolosis, a widespread disease of cattle and sheep caused by the liver flukes Fasciola hepatica and Fasciola gigantica, to be considered an emerging zoonotic disease. Chemotherapy is the main control measure available, and triclabendazole...

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Detalles Bibliográficos
Autores principales: Ferraro, Florencia, Merlino, Alicia, dell´Oca, Nicolás, Gil, Jorge, Tort, José F., Gonzalez, Mercedes, Cerecetto, Hugo, Cabrera, Mauricio, Corvo, Ileana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962987/
https://www.ncbi.nlm.nih.gov/pubmed/27463369
http://dx.doi.org/10.1371/journal.pntd.0004834

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