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Estimating rotavirus vaccine effectiveness in Japan using a screening method

Rotavirus gastroenteritis is a highly contagious, acute viral disease that imposes a significant health burden worldwide. In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, but vaccine coverage and effectiveness have not been evaluated. In the absence...

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Autores principales: Araki, Kaoru, Hara, Megumi, Sakanishi, Yuta, Shimanoe, Chisato, Nishida, Yuichiro, Matsuo, Muneaki, Tanaka, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963066/
https://www.ncbi.nlm.nih.gov/pubmed/26680277
http://dx.doi.org/10.1080/21645515.2015.1121337
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author Araki, Kaoru
Hara, Megumi
Sakanishi, Yuta
Shimanoe, Chisato
Nishida, Yuichiro
Matsuo, Muneaki
Tanaka, Keitaro
author_facet Araki, Kaoru
Hara, Megumi
Sakanishi, Yuta
Shimanoe, Chisato
Nishida, Yuichiro
Matsuo, Muneaki
Tanaka, Keitaro
author_sort Araki, Kaoru
collection PubMed
description Rotavirus gastroenteritis is a highly contagious, acute viral disease that imposes a significant health burden worldwide. In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, but vaccine coverage and effectiveness have not been evaluated. In the absence of a vaccination registry in Japan, vaccination coverage in the general population was estimated according to the number of vaccines supplied by the manufacturer, the number of children who received financial support for vaccination, and the size of the target population. Patients with rotavirus gastroenteritis were identified by reviewing the medical records of all children who consulted 6 major hospitals in Saga Prefecture with gastroenteritis symptoms. Vaccination status among these patients was investigated by reviewing their medical records or interviewing their guardians by telephone. Vaccine effectiveness was determined using a screening method. Vaccination coverage increased with time, and it was 2-times higher in municipalities where the vaccination fee was supported. In the 2012/13 season, vaccination coverage in Saga Prefecture was 14.9% whereas the proportion of patients vaccinated was 5.1% among those with clinically diagnosed rotavirus gastroenteritis and 1.9% among those hospitalized for rotavirus gastroenteritis. Thus, vaccine effectiveness was estimated as 69.5% and 88.8%, respectively. This is the first study to evaluate rotavirus vaccination coverage and effectiveness in Japan since vaccination began.
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spelling pubmed-49630662016-08-17 Estimating rotavirus vaccine effectiveness in Japan using a screening method Araki, Kaoru Hara, Megumi Sakanishi, Yuta Shimanoe, Chisato Nishida, Yuichiro Matsuo, Muneaki Tanaka, Keitaro Hum Vaccin Immunother Research Papers Rotavirus gastroenteritis is a highly contagious, acute viral disease that imposes a significant health burden worldwide. In Japan, rotavirus vaccines have been commercially available since 2011 for voluntary vaccination, but vaccine coverage and effectiveness have not been evaluated. In the absence of a vaccination registry in Japan, vaccination coverage in the general population was estimated according to the number of vaccines supplied by the manufacturer, the number of children who received financial support for vaccination, and the size of the target population. Patients with rotavirus gastroenteritis were identified by reviewing the medical records of all children who consulted 6 major hospitals in Saga Prefecture with gastroenteritis symptoms. Vaccination status among these patients was investigated by reviewing their medical records or interviewing their guardians by telephone. Vaccine effectiveness was determined using a screening method. Vaccination coverage increased with time, and it was 2-times higher in municipalities where the vaccination fee was supported. In the 2012/13 season, vaccination coverage in Saga Prefecture was 14.9% whereas the proportion of patients vaccinated was 5.1% among those with clinically diagnosed rotavirus gastroenteritis and 1.9% among those hospitalized for rotavirus gastroenteritis. Thus, vaccine effectiveness was estimated as 69.5% and 88.8%, respectively. This is the first study to evaluate rotavirus vaccination coverage and effectiveness in Japan since vaccination began. Taylor & Francis 2015-12-17 /pmc/articles/PMC4963066/ /pubmed/26680277 http://dx.doi.org/10.1080/21645515.2015.1121337 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Research Papers
Araki, Kaoru
Hara, Megumi
Sakanishi, Yuta
Shimanoe, Chisato
Nishida, Yuichiro
Matsuo, Muneaki
Tanaka, Keitaro
Estimating rotavirus vaccine effectiveness in Japan using a screening method
title Estimating rotavirus vaccine effectiveness in Japan using a screening method
title_full Estimating rotavirus vaccine effectiveness in Japan using a screening method
title_fullStr Estimating rotavirus vaccine effectiveness in Japan using a screening method
title_full_unstemmed Estimating rotavirus vaccine effectiveness in Japan using a screening method
title_short Estimating rotavirus vaccine effectiveness in Japan using a screening method
title_sort estimating rotavirus vaccine effectiveness in japan using a screening method
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963066/
https://www.ncbi.nlm.nih.gov/pubmed/26680277
http://dx.doi.org/10.1080/21645515.2015.1121337
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