Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the transition from aerobic glycolysis in neural progeni...

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Detalles Bibliográficos
Autores principales: Zheng, Xinde, Boyer, Leah, Jin, Mingji, Mertens, Jerome, Kim, Yongsung, Ma, Li, Hamm, Michael, Gage, Fred H, Hunter, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963198/
https://www.ncbi.nlm.nih.gov/pubmed/27282387
http://dx.doi.org/10.7554/eLife.13374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963198/
https://www.ncbi.nlm.nih.gov/pubmed/27282387
http://dx.doi.org/10.7554/eLife.13374

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