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Kinetics of initiating polypeptide elongation in an IRES-dependent system

The intergenic IRES of Cricket Paralysis Virus (CrPV-IRES) forms a tight complex with 80S ribosomes capable of initiating the cell-free synthesis of complete proteins in the absence of initiation factors. Such synthesis raises the question of what effect the necessary IRES dissociation from the tRNA...

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Detalles Bibliográficos
Autores principales: Zhang, Haibo, Ng, Martin Y, Chen, Yuanwei, Cooperman, Barry S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963199/
https://www.ncbi.nlm.nih.gov/pubmed/27253065
http://dx.doi.org/10.7554/eLife.13429