Cargando…
The expanding regulatory universe of p53 in gastrointestinal cancer
Tumor suppresser gene TP53 is one of the most frequently deleted or mutated genes in gastrointestinal cancers. As a transcription factor, p53 regulates a number of important protein coding genes to control cell cycle, cell death, DNA damage/repair, stemness, differentiation and other key cellular fu...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963207/ https://www.ncbi.nlm.nih.gov/pubmed/27508057 http://dx.doi.org/10.12688/f1000research.8363.1 |
_version_ | 1782444926845321216 |
---|---|
author | Fesler, Andrew Zhang, Ning Ju, Jingfang |
author_facet | Fesler, Andrew Zhang, Ning Ju, Jingfang |
author_sort | Fesler, Andrew |
collection | PubMed |
description | Tumor suppresser gene TP53 is one of the most frequently deleted or mutated genes in gastrointestinal cancers. As a transcription factor, p53 regulates a number of important protein coding genes to control cell cycle, cell death, DNA damage/repair, stemness, differentiation and other key cellular functions. In addition, p53 is also able to activate the expression of a number of small non-coding microRNAs (miRNAs) through direct binding to the promoter region of these miRNAs. Many miRNAs have been identified to be potential tumor suppressors by regulating key effecter target mRNAs. Our understanding of the regulatory network of p53 has recently expanded to include long non-coding RNAs (lncRNAs). Like miRNA, lncRNAs have been found to play important roles in cancer biology. With our increased understanding of the important functions of these non-coding RNAs and their relationship with p53, we are gaining exciting new insights into the biology and function of cells in response to various growth environment changes. In this review we summarize the current understanding of the ever expanding involvement of non-coding RNAs in the p53 regulatory network and its implications for our understanding of gastrointestinal cancer. |
format | Online Article Text |
id | pubmed-4963207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-49632072016-08-08 The expanding regulatory universe of p53 in gastrointestinal cancer Fesler, Andrew Zhang, Ning Ju, Jingfang F1000Res Review Tumor suppresser gene TP53 is one of the most frequently deleted or mutated genes in gastrointestinal cancers. As a transcription factor, p53 regulates a number of important protein coding genes to control cell cycle, cell death, DNA damage/repair, stemness, differentiation and other key cellular functions. In addition, p53 is also able to activate the expression of a number of small non-coding microRNAs (miRNAs) through direct binding to the promoter region of these miRNAs. Many miRNAs have been identified to be potential tumor suppressors by regulating key effecter target mRNAs. Our understanding of the regulatory network of p53 has recently expanded to include long non-coding RNAs (lncRNAs). Like miRNA, lncRNAs have been found to play important roles in cancer biology. With our increased understanding of the important functions of these non-coding RNAs and their relationship with p53, we are gaining exciting new insights into the biology and function of cells in response to various growth environment changes. In this review we summarize the current understanding of the ever expanding involvement of non-coding RNAs in the p53 regulatory network and its implications for our understanding of gastrointestinal cancer. F1000Research 2016-04-26 /pmc/articles/PMC4963207/ /pubmed/27508057 http://dx.doi.org/10.12688/f1000research.8363.1 Text en Copyright: © 2016 Fesler A et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Fesler, Andrew Zhang, Ning Ju, Jingfang The expanding regulatory universe of p53 in gastrointestinal cancer |
title | The expanding regulatory universe of p53 in gastrointestinal
cancer |
title_full | The expanding regulatory universe of p53 in gastrointestinal
cancer |
title_fullStr | The expanding regulatory universe of p53 in gastrointestinal
cancer |
title_full_unstemmed | The expanding regulatory universe of p53 in gastrointestinal
cancer |
title_short | The expanding regulatory universe of p53 in gastrointestinal
cancer |
title_sort | expanding regulatory universe of p53 in gastrointestinal
cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963207/ https://www.ncbi.nlm.nih.gov/pubmed/27508057 http://dx.doi.org/10.12688/f1000research.8363.1 |
work_keys_str_mv | AT feslerandrew theexpandingregulatoryuniverseofp53ingastrointestinalcancer AT zhangning theexpandingregulatoryuniverseofp53ingastrointestinalcancer AT jujingfang theexpandingregulatoryuniverseofp53ingastrointestinalcancer AT feslerandrew expandingregulatoryuniverseofp53ingastrointestinalcancer AT zhangning expandingregulatoryuniverseofp53ingastrointestinalcancer AT jujingfang expandingregulatoryuniverseofp53ingastrointestinalcancer |