Inhaled Nitric Oxide Use in Preterm Infants in California Neonatal Intensive Care Units

OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in Neonatal Intensive Care Unit (NICU) use. STUDY DESIGN: This was a retrospective cohort study of infants, 22–33+6/7 weeks gestational age (GA), during 2005–2013. Analyses were stratified by GA and included...

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Detalles Bibliográficos
Autores principales: Handley, Sara C., Steinhorn, Robin H., Hopper, Andrew O., Govindaswami, Balaji, Bhatt, Dilip R., Van Meurs, Krisa P., Ariagno, Ronald L., Gould, Jeffrey B., Lee, Henry C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963282/
https://www.ncbi.nlm.nih.gov/pubmed/27031320
http://dx.doi.org/10.1038/jp.2016.49
Descripción
Sumario:OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in Neonatal Intensive Care Unit (NICU) use. STUDY DESIGN: This was a retrospective cohort study of infants, 22–33+6/7 weeks gestational age (GA), during 2005–2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation. RESULT: Of 65 824 infants, 1 718 (2.61%) received iNO. Infants, 22–24+6/7 weeks GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n = 77, median hospital use rate 0.7%) used less iNO than regional NICUs (n = 23, median hospital use rate 5.8%). In 22–24+6/7 week GA infants the median rate in regional centers was 10.6% (hospital IQR 3.8%–22.6%). CONCLUSION: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.

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