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The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator
The Hfq protein was discovered in Escherichia coli as a host factor for bacteriophage Qβ RNA replication. Subsequent studies indicated that Hfq is a pleiotropic regulator of bacterial gene expression. The regulatory role of Hfq is ascribed mainly to its function as an RNA-chaperone, facilitating int...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963395/ https://www.ncbi.nlm.nih.gov/pubmed/27517037 http://dx.doi.org/10.3389/fmolb.2016.00036 |
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author | Cech, Grzegorz M. Szalewska-Pałasz, Agnieszka Kubiak, Krzysztof Malabirade, Antoine Grange, Wilfried Arluison, Veronique Węgrzyn, Grzegorz |
author_facet | Cech, Grzegorz M. Szalewska-Pałasz, Agnieszka Kubiak, Krzysztof Malabirade, Antoine Grange, Wilfried Arluison, Veronique Węgrzyn, Grzegorz |
author_sort | Cech, Grzegorz M. |
collection | PubMed |
description | The Hfq protein was discovered in Escherichia coli as a host factor for bacteriophage Qβ RNA replication. Subsequent studies indicated that Hfq is a pleiotropic regulator of bacterial gene expression. The regulatory role of Hfq is ascribed mainly to its function as an RNA-chaperone, facilitating interactions between bacterial non-coding RNA and its mRNA target. Thus, it modulates mRNA translation and stability. Nevertheless, Hfq is able to interact with DNA as well. Its role in the regulation of DNA-related processes has been demonstrated. In this mini-review, it is discussed how Hfq interacts with DNA and what is the role of this protein in regulation of DNA transactions. Particularly, Hfq has been demonstrated to be involved in the control of ColE1 plasmid DNA replication, transposition, and possibly also transcription. Possible mechanisms of these Hfq-mediated regulations are described and discussed. |
format | Online Article Text |
id | pubmed-4963395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49633952016-08-11 The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator Cech, Grzegorz M. Szalewska-Pałasz, Agnieszka Kubiak, Krzysztof Malabirade, Antoine Grange, Wilfried Arluison, Veronique Węgrzyn, Grzegorz Front Mol Biosci Molecular Biosciences The Hfq protein was discovered in Escherichia coli as a host factor for bacteriophage Qβ RNA replication. Subsequent studies indicated that Hfq is a pleiotropic regulator of bacterial gene expression. The regulatory role of Hfq is ascribed mainly to its function as an RNA-chaperone, facilitating interactions between bacterial non-coding RNA and its mRNA target. Thus, it modulates mRNA translation and stability. Nevertheless, Hfq is able to interact with DNA as well. Its role in the regulation of DNA-related processes has been demonstrated. In this mini-review, it is discussed how Hfq interacts with DNA and what is the role of this protein in regulation of DNA transactions. Particularly, Hfq has been demonstrated to be involved in the control of ColE1 plasmid DNA replication, transposition, and possibly also transcription. Possible mechanisms of these Hfq-mediated regulations are described and discussed. Frontiers Media S.A. 2016-07-28 /pmc/articles/PMC4963395/ /pubmed/27517037 http://dx.doi.org/10.3389/fmolb.2016.00036 Text en Copyright © 2016 Cech, Szalewska-Pałasz, Kubiak, Malabirade, Grange, Arluison and Węgrzyn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Cech, Grzegorz M. Szalewska-Pałasz, Agnieszka Kubiak, Krzysztof Malabirade, Antoine Grange, Wilfried Arluison, Veronique Węgrzyn, Grzegorz The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title | The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title_full | The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title_fullStr | The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title_full_unstemmed | The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title_short | The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator |
title_sort | escherichia coli hfq protein: an unattended dna-transactions regulator |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963395/ https://www.ncbi.nlm.nih.gov/pubmed/27517037 http://dx.doi.org/10.3389/fmolb.2016.00036 |
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