Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?

Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellula...

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Detalles Bibliográficos
Autores principales: Mazon, Mélody, Masi, Delphine, Carreau, Madeleine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963804/
https://www.ncbi.nlm.nih.gov/pubmed/27367730
http://dx.doi.org/10.3390/cancers8070062
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author Mazon, Mélody
Masi, Delphine
Carreau, Madeleine
author_facet Mazon, Mélody
Masi, Delphine
Carreau, Madeleine
author_sort Mazon, Mélody
collection PubMed
description Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologies and has now emerged as a potential biomarker of cancer progression and prognosis for several types of malignancies. Reducing the amount of circulating DKK1 may reveal a simple and efficient strategy to limit or reverse cancer growth. This review will provide an overview of the role of Dickkopf-1 in cancer and explore its potential use as a biomarker and therapeutic target.
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spelling pubmed-49638042016-08-03 Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer? Mazon, Mélody Masi, Delphine Carreau, Madeleine Cancers (Basel) Review Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologies and has now emerged as a potential biomarker of cancer progression and prognosis for several types of malignancies. Reducing the amount of circulating DKK1 may reveal a simple and efficient strategy to limit or reverse cancer growth. This review will provide an overview of the role of Dickkopf-1 in cancer and explore its potential use as a biomarker and therapeutic target. MDPI 2016-06-28 /pmc/articles/PMC4963804/ /pubmed/27367730 http://dx.doi.org/10.3390/cancers8070062 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mazon, Mélody
Masi, Delphine
Carreau, Madeleine
Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title_full Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title_fullStr Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title_full_unstemmed Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title_short Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?
title_sort modulating dickkopf-1: a strategy to monitor or treat cancer?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963804/
https://www.ncbi.nlm.nih.gov/pubmed/27367730
http://dx.doi.org/10.3390/cancers8070062
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