Cargando…

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

Most solid cancers contain regions of necrotic tissue. The extent of necrosis is associated with poor survival, most likely because it reflects aggressive tumour outgrowth and inflammation. Intravenously injected spores of anaerobic bacteria from the genus Clostridium infiltrate and selectively germ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mowday, Alexandra M., Guise, Christopher P., Ackerley, David F., Minton, Nigel P., Lambin, Philippe, Dubois, Ludwig J., Theys, Jan, Smaill, Jeff B., Patterson, Adam V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963805/ https://www.ncbi.nlm.nih.gov/pubmed/27367731 http://dx.doi.org/10.3390/cancers8070063

Ejemplares similares

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications
por: Mowday, Alexandra Marie, et al.
Publicado: (2020)

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials
por: Spiegelberg, Linda, et al.
Publicado: (2019)

Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications
por: Zhang, Yanchao, et al.
Publicado: (2022)

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
por: Ashoorzadeh, Amir, et al.
Publicado: (2022)

Pseudomonas aeruginosa NfsB and nitro-CBI-DEI – a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy
por: Green, Laura K, et al.
Publicado: (2013)

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
por: Guise, Christopher P., et al.
Publicado: (2014)

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy
por: Fu, Zhe, et al.
Publicado: (2021)

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3
por: Abbattista, Maria R., et al.
Publicado: (2021)

Combining radiotherapy with immunotherapy: the past, the present and the future
por: Van Limbergen, Evert J, et al.
Publicado: (2017)

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506
por: van der Wiel, Alexander M.A., et al.
Publicado: (2021)

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo
por: Heap, John T., et al.
Publicado: (2014)

Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel Delivery Vehicle for Cancer Immunotherapy
por: Kubiak, Aleksandra M., et al.
Publicado: (2021)

Sugar uptake by the solventogenic clostridia
por: Mitchell, Wilfrid J.
Publicado: (2016)

Sporulation in solventogenic and acetogenic clostridia
por: Diallo, Mamou, et al.
Publicado: (2021)

Solvent-Producing Clostridia Revisited
por: Jones, David T., et al.
Publicado: (2023)

Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide
por: Mowday, Alexandra M., et al.
Publicado: (2020)

Pathway dissection, regulation, engineering and application: lessons learned from biobutanol production by solventogenic clostridia
por: Li, Shubo, et al.
Publicado: (2020)

Medical Applications of Clostridia and Clostridial Toxins
por: Hale, Martha L., et al.
Publicado: (2012)

Major pathogenic Clostridia in human and progress toward the clostridial vaccines
por: Abdolmohammadi Khiav, Lida, et al.
Publicado: (2022)

Acetate adaptation of clostridia tyrobutyricum for improved fermentation production of butyrate
por: Jaros, Adam M, et al.
Publicado: (2013)

Type I Toxin-Antitoxin Systems in Clostridia
por: Soutourina, Olga
Publicado: (2019)

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia
por: Vanhomwegen, Jessica, et al.
Publicado: (2013)

Complete Genome Sequence of the Nonpathogenic Soil-Dwelling Bacterium Clostridium sporogenes Strain NCIMB 10696
por: Kubiak, Aleksandra M., et al.
Publicado: (2015)

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy
por: Green, Laura K., et al.
Publicado: (2013)

Harnessing lignocellulosic biomass for butanol production through clostridia for sustainable waste management: recent advances and perspectives
por: Palaniswamy, Sampathkumar, et al.
Publicado: (2023)

Faecal bile acids and clostridia in patients with breast cancer.
por: Murray, W. R., et al.
Publicado: (1980)

Faecal bile acids and clostridia in the aetiology of colorectal cancer.
por: Murray, W. R., et al.
Publicado: (1980)

Commensal Clostridia: leading players in the maintenance of gut homeostasis
por: Lopetuso, Loris R, et al.
Publicado: (2013)

Fermentation and Hydrogen Metabolism Affect Uranium Reduction by Clostridia
por: Gao, Weimin, et al.
Publicado: (2013)

Pan-Cellulosomics of Mesophilic Clostridia: Variations on a Theme
por: Dassa, Bareket, et al.
Publicado: (2017)

Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update
por: Cruz-Morales, Pablo, et al.
Publicado: (2019)

Vaccine Production to Protect Animals Against Pathogenic Clostridia
por: Zaragoza, Nicolas E., et al.
Publicado: (2019)

Vaccination against pathogenic clostridia in animals: a review
por: Abdolmohammadi Khiav, Lida, et al.
Publicado: (2021)

Profiling of the intestinal community of Clostridia: taxonomy and evolutionary analysis
por: Candeliere, Francesco, et al.
Publicado: (2023)

Towards continuous industrial bioprocessing with solventogenic and acetogenic clostridia: challenges, progress and perspectives
por: Vees, Charlotte Anne, et al.
Publicado: (2020)

Differentiating Botulinum Neurotoxin-Producing Clostridia with a Simple, Multiplex PCR Assay
por: Williamson, Charles H. D., et al.
Publicado: (2017)

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
por: Theys, J, et al.
Publicado: (2006)

Mucosal Immunization Against Pertussis: Lessons From the Past and Perspectives
por: Dubois, Violaine, et al.
Publicado: (2021)

Regulation of biomass degradation by alternative σ factors in cellulolytic clostridia
por: Ortiz de Ora, Lizett, et al.
Publicado: (2018)

Consolidated bioprocessing for butanol production of cellulolytic Clostridia: development and optimization
por: Wen, Zhiqiang, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p12u9fmn61lf9ht1tiq58mb1g5