Mammary Development and Breast Cancer: A Wnt Perspective

The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components co...

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Detalles Bibliográficos
Autores principales: Yu, Qing Cissy, Verheyen, Esther M., Zeng, Yi Arial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963807/
https://www.ncbi.nlm.nih.gov/pubmed/27420097
http://dx.doi.org/10.3390/cancers8070065
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author Yu, Qing Cissy
Verheyen, Esther M.
Zeng, Yi Arial
author_facet Yu, Qing Cissy
Verheyen, Esther M.
Zeng, Yi Arial
author_sort Yu, Qing Cissy
collection PubMed
description The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology.
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spelling pubmed-49638072016-08-03 Mammary Development and Breast Cancer: A Wnt Perspective Yu, Qing Cissy Verheyen, Esther M. Zeng, Yi Arial Cancers (Basel) Review The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. In this review, we will summarize the current knowledge of how the pathway regulates stem cells and normal development of the mammary gland, and discuss how its various components contribute to breast carcinoma pathology. MDPI 2016-07-13 /pmc/articles/PMC4963807/ /pubmed/27420097 http://dx.doi.org/10.3390/cancers8070065 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Qing Cissy
Verheyen, Esther M.
Zeng, Yi Arial
Mammary Development and Breast Cancer: A Wnt Perspective
title Mammary Development and Breast Cancer: A Wnt Perspective
title_full Mammary Development and Breast Cancer: A Wnt Perspective
title_fullStr Mammary Development and Breast Cancer: A Wnt Perspective
title_full_unstemmed Mammary Development and Breast Cancer: A Wnt Perspective
title_short Mammary Development and Breast Cancer: A Wnt Perspective
title_sort mammary development and breast cancer: a wnt perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963807/
https://www.ncbi.nlm.nih.gov/pubmed/27420097
http://dx.doi.org/10.3390/cancers8070065
work_keys_str_mv AT yuqingcissy mammarydevelopmentandbreastcancerawntperspective
AT verheyenestherm mammarydevelopmentandbreastcancerawntperspective
AT zengyiarial mammarydevelopmentandbreastcancerawntperspective

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