Impact of CDT Toxin on Human Diseases

Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, i...

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Autores principales: Faïs, Tiphanie, Delmas, Julien, Serres, Arnaud, Bonnet, Richard, Dalmasso, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963852/
https://www.ncbi.nlm.nih.gov/pubmed/27429000
http://dx.doi.org/10.3390/toxins8070220
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author Faïs, Tiphanie
Delmas, Julien
Serres, Arnaud
Bonnet, Richard
Dalmasso, Guillaume
author_facet Faïs, Tiphanie
Delmas, Julien
Serres, Arnaud
Bonnet, Richard
Dalmasso, Guillaume
author_sort Faïs, Tiphanie
collection PubMed
description Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.
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spelling pubmed-49638522016-08-03 Impact of CDT Toxin on Human Diseases Faïs, Tiphanie Delmas, Julien Serres, Arnaud Bonnet, Richard Dalmasso, Guillaume Toxins (Basel) Review Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects. MDPI 2016-07-15 /pmc/articles/PMC4963852/ /pubmed/27429000 http://dx.doi.org/10.3390/toxins8070220 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Faïs, Tiphanie
Delmas, Julien
Serres, Arnaud
Bonnet, Richard
Dalmasso, Guillaume
Impact of CDT Toxin on Human Diseases
title Impact of CDT Toxin on Human Diseases
title_full Impact of CDT Toxin on Human Diseases
title_fullStr Impact of CDT Toxin on Human Diseases
title_full_unstemmed Impact of CDT Toxin on Human Diseases
title_short Impact of CDT Toxin on Human Diseases
title_sort impact of cdt toxin on human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963852/
https://www.ncbi.nlm.nih.gov/pubmed/27429000
http://dx.doi.org/10.3390/toxins8070220
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AT serresarnaud impactofcdttoxinonhumandiseases
AT bonnetrichard impactofcdttoxinonhumandiseases
AT dalmassoguillaume impactofcdttoxinonhumandiseases

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