Interaction between TNF and BmooMP-Alpha-I, a Zinc Metalloprotease Derived from Bothrops moojeni Snake Venom, Promotes Direct Proteolysis of This Cytokine: Molecular Modeling and Docking at a Glance

Tumor necrosis factor (TNF) is a major cytokine in inflammatory processes and its deregulation plays a pivotal role in several diseases. Here, we report that a zinc metalloprotease extracted from Bothrops moojeni venom (BmooMP-alpha-I) inhibits TNF directly by promoting its degradation. This inhibit...

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Detalles Bibliográficos
Autores principales: Silva, Maraisa Cristina, Lopes Silva, Tamires, Silva, Murilo Vieira, Mota, Caroline Martins, Santiago, Fernanda Maria, Fonseca, Kelly Cortes, Oliveira, Fábio, Mineo, Tiago Wilson Patriarca, Mineo, José Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963855/
https://www.ncbi.nlm.nih.gov/pubmed/27447669
http://dx.doi.org/10.3390/toxins8070223

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